Role of the indirect pathway of the basal ganglia in perceptual decision making

Wei Wei, Jonathan E. Rubin, Xiao-Jing Wang

Research output: Contribution to journalArticle

Abstract

The basal ganglia (BG) play an important role in motor control, reinforcement learning, and perceptual decision making. Modeling and experimental evidence suggest that, in a speed-accuracy tradeoff, the corticostriatal pathway can adaptively adjust a decision threshold (the amount of information needed to make a choice). In this study, we go beyond the focus of previous works on the direct and hyperdirect pathways to examine the contribution of the indirect pathway of the BG system to decision making in a biophysically based spiking network model. We find that the mechanism of adjusting the decision threshold by plasticity of the corticostriatal connections is effective, provided that the indirect pathway counterbalances the direct pathway in their projections to the output nucleus. Furthermore, in our model, changes within basal ganglia connections similar to those that arise in parkinsonism give rise to strong beta oscillations. Specifically, beta oscillations are produced by an abnormal enhancement of the interactions between the subthalamic nucleus (STN) and the external segment of globus pallidus (GPe) in the indirect pathway, with an oscillation frequency that depends on the excitatory cortical input to the STN and the inhibitory input to the GPe from the striatum. In a parkinsonian state characterized by pronounced beta oscillations, the mean reaction time and range of threshold variation (a measure of behavioral flexibility) are significantly reduced compared with the normal state. Our work thus reveals a specific circuit mechanism for impairments of perceptual decision making associated with Parkinson’s disease.

Original languageEnglish (US)
Pages (from-to)4052-4064
Number of pages13
JournalJournal of Neuroscience
Volume35
Issue number9
DOIs
StatePublished - 2015

Fingerprint

Basal Ganglia
Subthalamic Nucleus
Decision Making
Globus Pallidus
Parkinsonian Disorders
Reaction Time
Parkinson Disease
Learning

Keywords

  • Basal ganglia
  • Decision making
  • Indirect pathway
  • Parkinson’s disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Role of the indirect pathway of the basal ganglia in perceptual decision making. / Wei, Wei; Rubin, Jonathan E.; Wang, Xiao-Jing.

In: Journal of Neuroscience, Vol. 35, No. 9, 2015, p. 4052-4064.

Research output: Contribution to journalArticle

@article{e726190e79a8438a9c8cc928c4d0e4f8,
title = "Role of the indirect pathway of the basal ganglia in perceptual decision making",
abstract = "The basal ganglia (BG) play an important role in motor control, reinforcement learning, and perceptual decision making. Modeling and experimental evidence suggest that, in a speed-accuracy tradeoff, the corticostriatal pathway can adaptively adjust a decision threshold (the amount of information needed to make a choice). In this study, we go beyond the focus of previous works on the direct and hyperdirect pathways to examine the contribution of the indirect pathway of the BG system to decision making in a biophysically based spiking network model. We find that the mechanism of adjusting the decision threshold by plasticity of the corticostriatal connections is effective, provided that the indirect pathway counterbalances the direct pathway in their projections to the output nucleus. Furthermore, in our model, changes within basal ganglia connections similar to those that arise in parkinsonism give rise to strong beta oscillations. Specifically, beta oscillations are produced by an abnormal enhancement of the interactions between the subthalamic nucleus (STN) and the external segment of globus pallidus (GPe) in the indirect pathway, with an oscillation frequency that depends on the excitatory cortical input to the STN and the inhibitory input to the GPe from the striatum. In a parkinsonian state characterized by pronounced beta oscillations, the mean reaction time and range of threshold variation (a measure of behavioral flexibility) are significantly reduced compared with the normal state. Our work thus reveals a specific circuit mechanism for impairments of perceptual decision making associated with Parkinson’s disease.",
keywords = "Basal ganglia, Decision making, Indirect pathway, Parkinson’s disease",
author = "Wei Wei and Rubin, {Jonathan E.} and Xiao-Jing Wang",
year = "2015",
doi = "10.1523/JNEUROSCI.3611-14.2015",
language = "English (US)",
volume = "35",
pages = "4052--4064",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "9",

}

TY - JOUR

T1 - Role of the indirect pathway of the basal ganglia in perceptual decision making

AU - Wei, Wei

AU - Rubin, Jonathan E.

AU - Wang, Xiao-Jing

PY - 2015

Y1 - 2015

N2 - The basal ganglia (BG) play an important role in motor control, reinforcement learning, and perceptual decision making. Modeling and experimental evidence suggest that, in a speed-accuracy tradeoff, the corticostriatal pathway can adaptively adjust a decision threshold (the amount of information needed to make a choice). In this study, we go beyond the focus of previous works on the direct and hyperdirect pathways to examine the contribution of the indirect pathway of the BG system to decision making in a biophysically based spiking network model. We find that the mechanism of adjusting the decision threshold by plasticity of the corticostriatal connections is effective, provided that the indirect pathway counterbalances the direct pathway in their projections to the output nucleus. Furthermore, in our model, changes within basal ganglia connections similar to those that arise in parkinsonism give rise to strong beta oscillations. Specifically, beta oscillations are produced by an abnormal enhancement of the interactions between the subthalamic nucleus (STN) and the external segment of globus pallidus (GPe) in the indirect pathway, with an oscillation frequency that depends on the excitatory cortical input to the STN and the inhibitory input to the GPe from the striatum. In a parkinsonian state characterized by pronounced beta oscillations, the mean reaction time and range of threshold variation (a measure of behavioral flexibility) are significantly reduced compared with the normal state. Our work thus reveals a specific circuit mechanism for impairments of perceptual decision making associated with Parkinson’s disease.

AB - The basal ganglia (BG) play an important role in motor control, reinforcement learning, and perceptual decision making. Modeling and experimental evidence suggest that, in a speed-accuracy tradeoff, the corticostriatal pathway can adaptively adjust a decision threshold (the amount of information needed to make a choice). In this study, we go beyond the focus of previous works on the direct and hyperdirect pathways to examine the contribution of the indirect pathway of the BG system to decision making in a biophysically based spiking network model. We find that the mechanism of adjusting the decision threshold by plasticity of the corticostriatal connections is effective, provided that the indirect pathway counterbalances the direct pathway in their projections to the output nucleus. Furthermore, in our model, changes within basal ganglia connections similar to those that arise in parkinsonism give rise to strong beta oscillations. Specifically, beta oscillations are produced by an abnormal enhancement of the interactions between the subthalamic nucleus (STN) and the external segment of globus pallidus (GPe) in the indirect pathway, with an oscillation frequency that depends on the excitatory cortical input to the STN and the inhibitory input to the GPe from the striatum. In a parkinsonian state characterized by pronounced beta oscillations, the mean reaction time and range of threshold variation (a measure of behavioral flexibility) are significantly reduced compared with the normal state. Our work thus reveals a specific circuit mechanism for impairments of perceptual decision making associated with Parkinson’s disease.

KW - Basal ganglia

KW - Decision making

KW - Indirect pathway

KW - Parkinson’s disease

UR - http://www.scopus.com/inward/record.url?scp=84924804277&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924804277&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.3611-14.2015

DO - 10.1523/JNEUROSCI.3611-14.2015

M3 - Article

VL - 35

SP - 4052

EP - 4064

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 9

ER -