Role of mitochondrial ion channels in cell death

Shin Young Ryu, Pablo M. Peixoto, Oscar Teijido, Laurent M. Dejean, Kathleen W. Kinnally

Research output: Contribution to journalArticle

Abstract

Ion channels located in the outer and inner mitochondrial membranes are key regulators of cellular signaling for life and death. Permeabilization of mitochondrial membranes is one of the most critical steps in the progression of several cell death pathways. The mitochondrial apoptosis-induced channel (MAC) and the mitochondrial permeability transition pore (mPTP) play major roles in these processes. Here, the most recent progress and current perspectives about the roles of MAC and mPTP in mitochondrial membrane permeabilization during cell death are presented. The crosstalk signaling of MAC and mPTP formation/activation mediated by cytosolic Ca 2+ signaling, Bcl-2 family proteins, and other mitochondrial ion channels is also discussed. Understanding the mechanisms that regulate opening and closing of MAC and mPTP has revealed new therapeutic targets that potentially could control cell death in pathologies such as cancer, ischemia/reperfusion injuries, and neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)255-263
Number of pages9
JournalBioFactors
Volume36
Issue number4
DOIs
StatePublished - Jul 2010

Fingerprint

Mitochondrial Membranes
Cell death
Ion Channels
Cell Death
Apoptosis
Membranes
Neurodegenerative diseases
Cell signaling
Mitochondrial Proteins
Pathology
Crosstalk
Reperfusion Injury
Neurodegenerative Diseases
Chemical activation
mitochondrial permeability transition pore
Neoplasms
Proteins
Therapeutics

Keywords

  • Apoptosis
  • Bcl-2 family proteins
  • Ca signaling
  • Cytochrome c
  • MAC
  • Mitochondrial ion channels
  • MPTP

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Ryu, S. Y., Peixoto, P. M., Teijido, O., Dejean, L. M., & Kinnally, K. W. (2010). Role of mitochondrial ion channels in cell death. BioFactors, 36(4), 255-263. https://doi.org/10.1002/biof.101

Role of mitochondrial ion channels in cell death. / Ryu, Shin Young; Peixoto, Pablo M.; Teijido, Oscar; Dejean, Laurent M.; Kinnally, Kathleen W.

In: BioFactors, Vol. 36, No. 4, 07.2010, p. 255-263.

Research output: Contribution to journalArticle

Ryu, SY, Peixoto, PM, Teijido, O, Dejean, LM & Kinnally, KW 2010, 'Role of mitochondrial ion channels in cell death', BioFactors, vol. 36, no. 4, pp. 255-263. https://doi.org/10.1002/biof.101
Ryu SY, Peixoto PM, Teijido O, Dejean LM, Kinnally KW. Role of mitochondrial ion channels in cell death. BioFactors. 2010 Jul;36(4):255-263. https://doi.org/10.1002/biof.101
Ryu, Shin Young ; Peixoto, Pablo M. ; Teijido, Oscar ; Dejean, Laurent M. ; Kinnally, Kathleen W. / Role of mitochondrial ion channels in cell death. In: BioFactors. 2010 ; Vol. 36, No. 4. pp. 255-263.
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