RNAi as a tool to study cell biology: Building the genome-phenome bridge

Research output: Contribution to journalArticle

Abstract

In the few short years since its discovery, RNA interference (RNAi) has revolutionized the functional analysis of genomes: both technical and conceptual approaches to the investigation of gene function are being transformed as a result of this new technology. Genome-scale RNAi analyses have already been performed in the model organisms Caenorhabditis elegans (in vivo) and Drosophila melanogaster (in cell lines), ushering in a new era of RNAi-based approaches to probing the inner workings of the cell. The transformation of complex phenotypic data into mineable 'digitized' formats is fostering the emergence of a new area of bioinformatics related to the phenome.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume17
Issue number1
DOIs
StatePublished - Feb 2005

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RNA Interference
Cell Biology
Genome
Foster Home Care
Caenorhabditis elegans
Computational Biology
Drosophila melanogaster
Technology
Cell Line
Genes

ASJC Scopus subject areas

  • Cell Biology

Cite this

RNAi as a tool to study cell biology : Building the genome-phenome bridge. / Gunsalus, Kristin C.; Piano, Fabio.

In: Current Opinion in Cell Biology, Vol. 17, No. 1, 02.2005, p. 3-8.

Research output: Contribution to journalArticle

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