RNA used to control a DNA rotary nanomachine

Hong Zhong, Nadrian Seeman

Research output: Contribution to journalArticle

Abstract

The PX-JX2 device is a robust sequence-dependent DNA nanomachine. It is controlled by the addition of DNA strands to the solution. The ability to control such devices with RNA will enable the machine to respond to signals generated by transcriptional logic circuits in vitro or, possibly, in vivo. The PX-JX2 device does not respond properly to RNA strands, so we have adapted the signaling method by using a cover-strand strategy, This approach entails using DNA control strands that contain sequence regions to set the device to either state. An RNA strand is used to mask one of these two regions, enabling the machine to assume the state corresponding to the unmasked region.

Original languageEnglish (US)
Pages (from-to)2899-2903
Number of pages5
JournalNano Letters
Volume6
Issue number12
DOIs
StatePublished - Dec 2006

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RNA
strands
DNA
deoxyribonucleic acid
Logic circuits
Masks
logic circuits
control equipment
masks

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

RNA used to control a DNA rotary nanomachine. / Zhong, Hong; Seeman, Nadrian.

In: Nano Letters, Vol. 6, No. 12, 12.2006, p. 2899-2903.

Research output: Contribution to journalArticle

Zhong, Hong ; Seeman, Nadrian. / RNA used to control a DNA rotary nanomachine. In: Nano Letters. 2006 ; Vol. 6, No. 12. pp. 2899-2903.
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