Reversal of the morphological effects of monocular deprivation in the kitten's lateral geniculate nucleus

M. R. Dursteler, L. J. Garey, J. Anthony Movshon

Research output: Contribution to journalArticle

Abstract

11 kittens were deprived of vision in 1 eye until the age of between 5 and 14 wk. Their eyes were then reverse sutured, they were allowed to survive for a further 3-63 days, and their brains were then examined histologically. Measurement of the cross sectional area of cells in the lateral geniculate nucleus (LGN) showed that when the reversal of lid suture was performed at the age of 8 or 14 wk, the mean cell size was smaller in laminae connected to the initially closed right eye than it was in other laminae. When the reversal of lid suture took place at 5 or 6 wk of age there was a reversal of interlaminar size differences: the initially deprived eye was then connected to laminae containing larger cells. Even within 3 days after the reversal of lid suture, most of the morphological effects of the initial suture had been abolished, and they were fully reversed within 12 days. These results are compared with physiological changes in the visual cortex of these and similarly reared animals.

Original languageEnglish (US)
Pages (from-to)189-210
Number of pages22
JournalJournal of Physiology
Volume261
Issue number1
StatePublished - 1976

Fingerprint

Geniculate Bodies
Sutures
Visual Cortex
Cell Size
Brain

ASJC Scopus subject areas

  • Physiology

Cite this

Reversal of the morphological effects of monocular deprivation in the kitten's lateral geniculate nucleus. / Dursteler, M. R.; Garey, L. J.; Movshon, J. Anthony.

In: Journal of Physiology, Vol. 261, No. 1, 1976, p. 189-210.

Research output: Contribution to journalArticle

@article{2bb17b7b1376474997cd85305afb3ddd,
title = "Reversal of the morphological effects of monocular deprivation in the kitten's lateral geniculate nucleus",
abstract = "11 kittens were deprived of vision in 1 eye until the age of between 5 and 14 wk. Their eyes were then reverse sutured, they were allowed to survive for a further 3-63 days, and their brains were then examined histologically. Measurement of the cross sectional area of cells in the lateral geniculate nucleus (LGN) showed that when the reversal of lid suture was performed at the age of 8 or 14 wk, the mean cell size was smaller in laminae connected to the initially closed right eye than it was in other laminae. When the reversal of lid suture took place at 5 or 6 wk of age there was a reversal of interlaminar size differences: the initially deprived eye was then connected to laminae containing larger cells. Even within 3 days after the reversal of lid suture, most of the morphological effects of the initial suture had been abolished, and they were fully reversed within 12 days. These results are compared with physiological changes in the visual cortex of these and similarly reared animals.",
author = "Dursteler, {M. R.} and Garey, {L. J.} and Movshon, {J. Anthony}",
year = "1976",
language = "English (US)",
volume = "261",
pages = "189--210",
journal = "Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Reversal of the morphological effects of monocular deprivation in the kitten's lateral geniculate nucleus

AU - Dursteler, M. R.

AU - Garey, L. J.

AU - Movshon, J. Anthony

PY - 1976

Y1 - 1976

N2 - 11 kittens were deprived of vision in 1 eye until the age of between 5 and 14 wk. Their eyes were then reverse sutured, they were allowed to survive for a further 3-63 days, and their brains were then examined histologically. Measurement of the cross sectional area of cells in the lateral geniculate nucleus (LGN) showed that when the reversal of lid suture was performed at the age of 8 or 14 wk, the mean cell size was smaller in laminae connected to the initially closed right eye than it was in other laminae. When the reversal of lid suture took place at 5 or 6 wk of age there was a reversal of interlaminar size differences: the initially deprived eye was then connected to laminae containing larger cells. Even within 3 days after the reversal of lid suture, most of the morphological effects of the initial suture had been abolished, and they were fully reversed within 12 days. These results are compared with physiological changes in the visual cortex of these and similarly reared animals.

AB - 11 kittens were deprived of vision in 1 eye until the age of between 5 and 14 wk. Their eyes were then reverse sutured, they were allowed to survive for a further 3-63 days, and their brains were then examined histologically. Measurement of the cross sectional area of cells in the lateral geniculate nucleus (LGN) showed that when the reversal of lid suture was performed at the age of 8 or 14 wk, the mean cell size was smaller in laminae connected to the initially closed right eye than it was in other laminae. When the reversal of lid suture took place at 5 or 6 wk of age there was a reversal of interlaminar size differences: the initially deprived eye was then connected to laminae containing larger cells. Even within 3 days after the reversal of lid suture, most of the morphological effects of the initial suture had been abolished, and they were fully reversed within 12 days. These results are compared with physiological changes in the visual cortex of these and similarly reared animals.

UR - http://www.scopus.com/inward/record.url?scp=0017161047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017161047&partnerID=8YFLogxK

M3 - Article

C2 - 994029

AN - SCOPUS:0017161047

VL - 261

SP - 189

EP - 210

JO - Journal of Physiology

JF - Journal of Physiology

SN - 0022-3751

IS - 1

ER -