Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder

IBIS Network

    Research output: Contribution to journalArticle

    Abstract

    Background: Restricted and repetitive behaviors (RRBs), detectable by 12 months in many infants in whom autism spectrum disorder (ASD) is later diagnosed, may represent some of the earliest behavioral markers of ASD. However, brain function underlying the emergence of these key behaviors remains unknown. Methods: Behavioral and resting-state functional connectivity (fc) magnetic resonance imaging data were collected from 167 children at high and low familial risk for ASD at 12 and 24 months (n = 38 at both time points). Twenty infants met criteria for ASD at 24 months. We divided RRBs into four subcategories (restricted, stereotyped, ritualistic/sameness, self-injurious) and used a data-driven approach to identify functional brain networks associated with the development of each RRB subcategory. Results: Higher scores for ritualistic/sameness behavior were associated with less positive fc between visual and control networks at 12 and 24 months. Ritualistic/sameness and stereotyped behaviors were associated with less positive fc between visual and default mode networks at 12 months. At 24 months, stereotyped and restricted behaviors were associated with more positive fc between default mode and control networks. Additionally, at 24 months, stereotyped behavior was associated with more positive fc between dorsal attention and subcortical networks, whereas restricted behavior was associated with more positive fc between default mode and dorsal attention networks. No significant network-level associations were observed for self-injurious behavior. Conclusions: These observations mark the earliest known description of functional brain systems underlying RRBs, reinforce the construct validity of RRB subcategories in infants, and implicate specific neural substrates for future interventions targeting RRBs.

    Original languageEnglish (US)
    Pages (from-to)50-61
    Number of pages12
    JournalBiological Psychiatry: Cognitive Neuroscience and Neuroimaging
    Volume4
    Issue number1
    DOIs
    StatePublished - Jan 1 2019

    Fingerprint

    Brain
    Stereotyped Behavior
    Autism Spectrum Disorder
    Self-Injurious Behavior
    Magnetic Resonance Imaging

    Keywords

    • Autism spectrum disorder
    • Brain development
    • Functional connectivity
    • Functional magnetic resonance imaging
    • Infant
    • Restricted and repetitive behavior

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging
    • Cognitive Neuroscience
    • Clinical Neurology
    • Biological Psychiatry

    Cite this

    @article{449fb83618044588ad473b1141c3895a,
    title = "Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder",
    abstract = "Background: Restricted and repetitive behaviors (RRBs), detectable by 12 months in many infants in whom autism spectrum disorder (ASD) is later diagnosed, may represent some of the earliest behavioral markers of ASD. However, brain function underlying the emergence of these key behaviors remains unknown. Methods: Behavioral and resting-state functional connectivity (fc) magnetic resonance imaging data were collected from 167 children at high and low familial risk for ASD at 12 and 24 months (n = 38 at both time points). Twenty infants met criteria for ASD at 24 months. We divided RRBs into four subcategories (restricted, stereotyped, ritualistic/sameness, self-injurious) and used a data-driven approach to identify functional brain networks associated with the development of each RRB subcategory. Results: Higher scores for ritualistic/sameness behavior were associated with less positive fc between visual and control networks at 12 and 24 months. Ritualistic/sameness and stereotyped behaviors were associated with less positive fc between visual and default mode networks at 12 months. At 24 months, stereotyped and restricted behaviors were associated with more positive fc between default mode and control networks. Additionally, at 24 months, stereotyped behavior was associated with more positive fc between dorsal attention and subcortical networks, whereas restricted behavior was associated with more positive fc between default mode and dorsal attention networks. No significant network-level associations were observed for self-injurious behavior. Conclusions: These observations mark the earliest known description of functional brain systems underlying RRBs, reinforce the construct validity of RRB subcategories in infants, and implicate specific neural substrates for future interventions targeting RRBs.",
    keywords = "Autism spectrum disorder, Brain development, Functional connectivity, Functional magnetic resonance imaging, Infant, Restricted and repetitive behavior",
    author = "{IBIS Network} and McKinnon, {Claire J.} and Eggebrecht, {Adam T.} and Alexandre Todorov and Wolff, {Jason J.} and Elison, {Jed T.} and Adams, {Chloe M.} and Snyder, {Abraham Z.} and Estes, {Annette M.} and Lonnie Zwaigenbaum and Botteron, {Kelly N.} and McKinstry, {Robert C.} and Natasha Marrus and Alan Evans and Hazlett, {Heather C.} and Dager, {Stephen R.} and Paterson, {Sarah J.} and Juhi Pandey and Schultz, {Robert T.} and Styner, {Martin A.} and Guido Gerig and Schlaggar, {Bradley L.} and Petersen, {Steven E.} and Joseph Piven and Pruett, {John R.}",
    year = "2019",
    month = "1",
    day = "1",
    doi = "10.1016/j.bpsc.2018.09.008",
    language = "English (US)",
    volume = "4",
    pages = "50--61",
    journal = "Biological Psychiatry: Cognitive Neuroscience and Neuroimaging",
    issn = "2451-9022",
    publisher = "Elsevier Inc.",
    number = "1",

    }

    TY - JOUR

    T1 - Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder

    AU - IBIS Network

    AU - McKinnon, Claire J.

    AU - Eggebrecht, Adam T.

    AU - Todorov, Alexandre

    AU - Wolff, Jason J.

    AU - Elison, Jed T.

    AU - Adams, Chloe M.

    AU - Snyder, Abraham Z.

    AU - Estes, Annette M.

    AU - Zwaigenbaum, Lonnie

    AU - Botteron, Kelly N.

    AU - McKinstry, Robert C.

    AU - Marrus, Natasha

    AU - Evans, Alan

    AU - Hazlett, Heather C.

    AU - Dager, Stephen R.

    AU - Paterson, Sarah J.

    AU - Pandey, Juhi

    AU - Schultz, Robert T.

    AU - Styner, Martin A.

    AU - Gerig, Guido

    AU - Schlaggar, Bradley L.

    AU - Petersen, Steven E.

    AU - Piven, Joseph

    AU - Pruett, John R.

    PY - 2019/1/1

    Y1 - 2019/1/1

    N2 - Background: Restricted and repetitive behaviors (RRBs), detectable by 12 months in many infants in whom autism spectrum disorder (ASD) is later diagnosed, may represent some of the earliest behavioral markers of ASD. However, brain function underlying the emergence of these key behaviors remains unknown. Methods: Behavioral and resting-state functional connectivity (fc) magnetic resonance imaging data were collected from 167 children at high and low familial risk for ASD at 12 and 24 months (n = 38 at both time points). Twenty infants met criteria for ASD at 24 months. We divided RRBs into four subcategories (restricted, stereotyped, ritualistic/sameness, self-injurious) and used a data-driven approach to identify functional brain networks associated with the development of each RRB subcategory. Results: Higher scores for ritualistic/sameness behavior were associated with less positive fc between visual and control networks at 12 and 24 months. Ritualistic/sameness and stereotyped behaviors were associated with less positive fc between visual and default mode networks at 12 months. At 24 months, stereotyped and restricted behaviors were associated with more positive fc between default mode and control networks. Additionally, at 24 months, stereotyped behavior was associated with more positive fc between dorsal attention and subcortical networks, whereas restricted behavior was associated with more positive fc between default mode and dorsal attention networks. No significant network-level associations were observed for self-injurious behavior. Conclusions: These observations mark the earliest known description of functional brain systems underlying RRBs, reinforce the construct validity of RRB subcategories in infants, and implicate specific neural substrates for future interventions targeting RRBs.

    AB - Background: Restricted and repetitive behaviors (RRBs), detectable by 12 months in many infants in whom autism spectrum disorder (ASD) is later diagnosed, may represent some of the earliest behavioral markers of ASD. However, brain function underlying the emergence of these key behaviors remains unknown. Methods: Behavioral and resting-state functional connectivity (fc) magnetic resonance imaging data were collected from 167 children at high and low familial risk for ASD at 12 and 24 months (n = 38 at both time points). Twenty infants met criteria for ASD at 24 months. We divided RRBs into four subcategories (restricted, stereotyped, ritualistic/sameness, self-injurious) and used a data-driven approach to identify functional brain networks associated with the development of each RRB subcategory. Results: Higher scores for ritualistic/sameness behavior were associated with less positive fc between visual and control networks at 12 and 24 months. Ritualistic/sameness and stereotyped behaviors were associated with less positive fc between visual and default mode networks at 12 months. At 24 months, stereotyped and restricted behaviors were associated with more positive fc between default mode and control networks. Additionally, at 24 months, stereotyped behavior was associated with more positive fc between dorsal attention and subcortical networks, whereas restricted behavior was associated with more positive fc between default mode and dorsal attention networks. No significant network-level associations were observed for self-injurious behavior. Conclusions: These observations mark the earliest known description of functional brain systems underlying RRBs, reinforce the construct validity of RRB subcategories in infants, and implicate specific neural substrates for future interventions targeting RRBs.

    KW - Autism spectrum disorder

    KW - Brain development

    KW - Functional connectivity

    KW - Functional magnetic resonance imaging

    KW - Infant

    KW - Restricted and repetitive behavior

    UR - http://www.scopus.com/inward/record.url?scp=85059926247&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85059926247&partnerID=8YFLogxK

    U2 - 10.1016/j.bpsc.2018.09.008

    DO - 10.1016/j.bpsc.2018.09.008

    M3 - Article

    VL - 4

    SP - 50

    EP - 61

    JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

    JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

    SN - 2451-9022

    IS - 1

    ER -