Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder

IBIS Network

    Research output: Contribution to journalArticle

    Abstract

    Background: Restricted and repetitive behaviors (RRBs), detectable by 12 months in many infants in whom autism spectrum disorder (ASD) is later diagnosed, may represent some of the earliest behavioral markers of ASD. However, brain function underlying the emergence of these key behaviors remains unknown. Methods: Behavioral and resting-state functional connectivity (fc) magnetic resonance imaging data were collected from 167 children at high and low familial risk for ASD at 12 and 24 months (n = 38 at both time points). Twenty infants met criteria for ASD at 24 months. We divided RRBs into four subcategories (restricted, stereotyped, ritualistic/sameness, self-injurious) and used a data-driven approach to identify functional brain networks associated with the development of each RRB subcategory. Results: Higher scores for ritualistic/sameness behavior were associated with less positive fc between visual and control networks at 12 and 24 months. Ritualistic/sameness and stereotyped behaviors were associated with less positive fc between visual and default mode networks at 12 months. At 24 months, stereotyped and restricted behaviors were associated with more positive fc between default mode and control networks. Additionally, at 24 months, stereotyped behavior was associated with more positive fc between dorsal attention and subcortical networks, whereas restricted behavior was associated with more positive fc between default mode and dorsal attention networks. No significant network-level associations were observed for self-injurious behavior. Conclusions: These observations mark the earliest known description of functional brain systems underlying RRBs, reinforce the construct validity of RRB subcategories in infants, and implicate specific neural substrates for future interventions targeting RRBs.

    Original languageEnglish (US)
    Pages (from-to)50-61
    Number of pages12
    JournalBiological Psychiatry: Cognitive Neuroscience and Neuroimaging
    Volume4
    Issue number1
    DOIs
    StatePublished - Jan 2019

      Fingerprint

    Keywords

    • Autism spectrum disorder
    • Brain development
    • Functional connectivity
    • Functional magnetic resonance imaging
    • Infant
    • Restricted and repetitive behavior

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging
    • Cognitive Neuroscience
    • Clinical Neurology
    • Biological Psychiatry

    Cite this