Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness

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    Research output: Contribution to journalArticle

    Abstract

    Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI.

    Original languageEnglish (US)
    Article numbere0188122
    JournalPLoS One
    Volume12
    Issue number11
    DOIs
    StatePublished - Nov 1 2017

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    Wakefulness
    sleep
    Sleep
    Magnetic Resonance Imaging
    magnetic resonance imaging
    human development
    Human Development
    Artifacts
    Brain
    brain

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)

    Cite this

    Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness. / IBIS Network.

    In: PLoS One, Vol. 12, No. 11, e0188122, 01.11.2017.

    Research output: Contribution to journalArticle

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    abstract = "Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI.",
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    AU - Wolff, Jason J.

    AU - Botteron, Kelly N.

    AU - Dager, Stephen

    AU - Estes, Annette M.

    AU - Evans, Alan

    AU - Gerig, Guido

    AU - Hazlett, Heather C.

    AU - Paterson, Sarah J.

    AU - Schultz, Robert T.

    AU - Styner, Martin A.

    AU - Zwaigenbaum, Lonnie

    AU - Chappell, C.

    AU - Estes, A.

    AU - Shaw, D.

    AU - Botteron, K.

    AU - McKinstry, R.

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    AU - Pruett, J.

    AU - Schultz, R.

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    AU - Evans, A. C.

    AU - Collins, D. L.

    AU - Pike, G. B.

    AU - Fonov, V.

    AU - Kostopoulos, P.

    AU - Das, S.

    AU - Styner, M.

    AU - Gu, H.

    AU - Schlaggar, Bradley L.

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