Resonance fluctuations of a whispering gallery mode biosensor by particles undergoing Brownian motion

D. Keng, S. R. McAnanama, I. Teraoka, S. Arnold

Research output: Contribution to journalArticle

Abstract

Nanoparticles suspended in the vicinity of a whispering gallery mode (WGM) biosensor are detected from fluctuations in the driving light-guide transmission. These fluctuations are described by Brownian particles perturbing the resonance wavelength in reaction to being polarized by the WGM's evanescent field. Comparison between the autocorrelation of the measured fluctuations and theory provides a first order approximation for the nanoparticle size and lays the basis for future studies of interfacial dynamics. With this advance, the WGM biosensor goes beyond low-frequency measurements of adsorption and desorption and into a world which has been dominated by fluorescence correlation spectroscopy, but without labels.

Original languageEnglish (US)
Article number103902
JournalApplied Physics Letters
Volume91
Issue number10
DOIs
StatePublished - 2007

Fingerprint

whispering gallery modes
bioinstrumentation
nanoparticles
frequency measurement
autocorrelation
desorption
low frequencies
fluorescence
adsorption
approximation
wavelengths
spectroscopy

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Resonance fluctuations of a whispering gallery mode biosensor by particles undergoing Brownian motion. / Keng, D.; McAnanama, S. R.; Teraoka, I.; Arnold, S.

In: Applied Physics Letters, Vol. 91, No. 10, 103902, 2007.

Research output: Contribution to journalArticle

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