Resistance to HIV Infection

M. Marmor, K. Hertzmark, S. M. Thomas, P. N. Halkitis, M. Vogler

Research output: Contribution to journalArticle

Abstract

The biological correlates of an effective immune response that could contain or prevent HIV infection remain elusive despite substantial scientific accomplishments in understanding the interactions among the virus, the individual and the community. The observation that some individuals appear to possess resistance to HIV infection or its consequences has generated a host of epidemiologic investigations to identify biological or behavioral characteristics of these individuals. These data might hold the keys to developing appropriate strategies for mimicking the effective responses of those who appear immune. In this paper we review genetic mechanisms including the role of chemokines and their receptors, cytokines, host genetic immune response to HIV infection, local immune response correlating with behavioral variables, co-infection and immune based mechanisms that have been elucidated so far. We offer suggestions for how to use these observations as platforms for future research to further understand natural resistance to HIV infection through cohort studies, population genotype sampling, mathematical modeling of virus-host interactions and behavioral analyses.

Original languageEnglish (US)
Pages (from-to)5-17
Number of pages13
JournalJournal of Urban Health
Volume83
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

HIV Infections
mathematical modeling
interaction
Viruses
Chemokine Receptors
Coinfection
Innate Immunity
Cohort Studies
Genotype
Cytokines
community
Population

Keywords

  • HIV infection
  • Progression
  • Resistance
  • Susceptibility

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Marmor, M., Hertzmark, K., Thomas, S. M., Halkitis, P. N., & Vogler, M. (2006). Resistance to HIV Infection. Journal of Urban Health, 83(1), 5-17. https://doi.org/10.1007/s11524-005-9003-8

Resistance to HIV Infection. / Marmor, M.; Hertzmark, K.; Thomas, S. M.; Halkitis, P. N.; Vogler, M.

In: Journal of Urban Health, Vol. 83, No. 1, 01.2006, p. 5-17.

Research output: Contribution to journalArticle

Marmor, M, Hertzmark, K, Thomas, SM, Halkitis, PN & Vogler, M 2006, 'Resistance to HIV Infection', Journal of Urban Health, vol. 83, no. 1, pp. 5-17. https://doi.org/10.1007/s11524-005-9003-8
Marmor M, Hertzmark K, Thomas SM, Halkitis PN, Vogler M. Resistance to HIV Infection. Journal of Urban Health. 2006 Jan;83(1):5-17. https://doi.org/10.1007/s11524-005-9003-8
Marmor, M. ; Hertzmark, K. ; Thomas, S. M. ; Halkitis, P. N. ; Vogler, M. / Resistance to HIV Infection. In: Journal of Urban Health. 2006 ; Vol. 83, No. 1. pp. 5-17.
@article{a81a22d469ca417281af63d0b9ed410d,
title = "Resistance to HIV Infection",
abstract = "The biological correlates of an effective immune response that could contain or prevent HIV infection remain elusive despite substantial scientific accomplishments in understanding the interactions among the virus, the individual and the community. The observation that some individuals appear to possess resistance to HIV infection or its consequences has generated a host of epidemiologic investigations to identify biological or behavioral characteristics of these individuals. These data might hold the keys to developing appropriate strategies for mimicking the effective responses of those who appear immune. In this paper we review genetic mechanisms including the role of chemokines and their receptors, cytokines, host genetic immune response to HIV infection, local immune response correlating with behavioral variables, co-infection and immune based mechanisms that have been elucidated so far. We offer suggestions for how to use these observations as platforms for future research to further understand natural resistance to HIV infection through cohort studies, population genotype sampling, mathematical modeling of virus-host interactions and behavioral analyses.",
keywords = "HIV infection, Progression, Resistance, Susceptibility",
author = "M. Marmor and K. Hertzmark and Thomas, {S. M.} and Halkitis, {P. N.} and M. Vogler",
year = "2006",
month = "1",
doi = "10.1007/s11524-005-9003-8",
language = "English (US)",
volume = "83",
pages = "5--17",
journal = "Journal of Urban Health",
issn = "1099-3460",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "1",

}

TY - JOUR

T1 - Resistance to HIV Infection

AU - Marmor, M.

AU - Hertzmark, K.

AU - Thomas, S. M.

AU - Halkitis, P. N.

AU - Vogler, M.

PY - 2006/1

Y1 - 2006/1

N2 - The biological correlates of an effective immune response that could contain or prevent HIV infection remain elusive despite substantial scientific accomplishments in understanding the interactions among the virus, the individual and the community. The observation that some individuals appear to possess resistance to HIV infection or its consequences has generated a host of epidemiologic investigations to identify biological or behavioral characteristics of these individuals. These data might hold the keys to developing appropriate strategies for mimicking the effective responses of those who appear immune. In this paper we review genetic mechanisms including the role of chemokines and their receptors, cytokines, host genetic immune response to HIV infection, local immune response correlating with behavioral variables, co-infection and immune based mechanisms that have been elucidated so far. We offer suggestions for how to use these observations as platforms for future research to further understand natural resistance to HIV infection through cohort studies, population genotype sampling, mathematical modeling of virus-host interactions and behavioral analyses.

AB - The biological correlates of an effective immune response that could contain or prevent HIV infection remain elusive despite substantial scientific accomplishments in understanding the interactions among the virus, the individual and the community. The observation that some individuals appear to possess resistance to HIV infection or its consequences has generated a host of epidemiologic investigations to identify biological or behavioral characteristics of these individuals. These data might hold the keys to developing appropriate strategies for mimicking the effective responses of those who appear immune. In this paper we review genetic mechanisms including the role of chemokines and their receptors, cytokines, host genetic immune response to HIV infection, local immune response correlating with behavioral variables, co-infection and immune based mechanisms that have been elucidated so far. We offer suggestions for how to use these observations as platforms for future research to further understand natural resistance to HIV infection through cohort studies, population genotype sampling, mathematical modeling of virus-host interactions and behavioral analyses.

KW - HIV infection

KW - Progression

KW - Resistance

KW - Susceptibility

UR - http://www.scopus.com/inward/record.url?scp=33745054989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745054989&partnerID=8YFLogxK

U2 - 10.1007/s11524-005-9003-8

DO - 10.1007/s11524-005-9003-8

M3 - Article

VL - 83

SP - 5

EP - 17

JO - Journal of Urban Health

JF - Journal of Urban Health

SN - 1099-3460

IS - 1

ER -