Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy

Cheryl D. Conrad, Joseph E. LeDoux, Ana María Magariños, Bruce S. McEwen

Research output: Contribution to journalArticle

Abstract

This study investigated whether 21 days of restraint stress (6 hr/day) and the subsequent hippocampal dendritic atrophy would affect fear conditioning, a memory task with hippocampal-dependent and hippocampal- independent components. Restraint-stressed rats were injected daily (21 days) with tianeptine (10 mg/kg; to prevent hippocampal atrophy) or vehicle then tested on fear conditioning (Days 23-25, with 2 tone-shock pairings) and open field (Day 25). Restraint stress enhanced freezing to context (hippocampal-dependent behavior) and tone (hippocampal-independent) and decreased open-field exploration, irrespective of whether tianeptine was given. Results confirmed that stress produced CA3 dendritic atrophy and tianeptine prevented it. Moreover, CA3 dendritic atrophy was not permanent but reversed to control levels by 10 days after the cessation of restraint stress. These data argue that different neural substrates underlie spatial recognition memory and fear conditioning.

Original languageEnglish (US)
Pages (from-to)902-913
Number of pages12
JournalBehavioral Neuroscience
Volume113
Issue number5
DOIs
StatePublished - 1999

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tianeptine
Fear
Atrophy
Freezing
Shock
Conditioning (Psychology)

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy. / Conrad, Cheryl D.; LeDoux, Joseph E.; Magariños, Ana María; McEwen, Bruce S.

In: Behavioral Neuroscience, Vol. 113, No. 5, 1999, p. 902-913.

Research output: Contribution to journalArticle

Conrad, Cheryl D. ; LeDoux, Joseph E. ; Magariños, Ana María ; McEwen, Bruce S. / Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy. In: Behavioral Neuroscience. 1999 ; Vol. 113, No. 5. pp. 902-913.
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