Remodeling of the fovea in Parkinson disease

B. Spund, Y. Ding, T. Liu, Ivan Selesnick, S. Glazman, E. M. Shrier, I. Bodis-Wollner

Research output: Contribution to journalArticle

Abstract

To quantify the thickness of the inner retinal layers in the foveal pit where the nerve fiber layer (NFL) is absent, and quantify changes in the ganglion cells and inner plexiform layer. Pixel-by-pixel volumetric measurements were obtained via Spectral-Domain optical coherence tomography (SD-OCT) from 50 eyes of Parkinson disease (PD) (n = 30) and 50 eyes of healthy control subjects (n = 27). Receiver operating characteristics (ROC) were used to classify individual subjects with respect to sensitivity and specificity calculations at each perifoveolar distance. Three-dimensional topographic maps of the healthy and PD foveal pit were created. The foveal pit is thinner and broader in PD. The difference becomes evident in an annular zone between 0.5 and 2 mm from the foveola and the optimal (ROC-defined) zone is from 0.75 to 1.5 mm. This zone is nearly devoid of NFL and partially overlaps the foveal avascular zone. About 78 % of PD eyes can be discriminated from HC eyes based on this zone. ROC applied to OCT pixel-by-pixel analysis helps to discriminate PD from HC retinae. Remodeling of the foveal architecture is significant because it may provide a visible and quantifiable signature of PD. The specific location of remodeling in the fovea raises a novel concept for exploring the mechanism of oxidative stress on retinal neurons in PD. OCT is a promising quantitative tool in PD research. However, larger scale studies are needed before the method can be applied to clinical follow-ups.

Original languageEnglish (US)
Pages (from-to)745-753
Number of pages9
JournalJournal of Neural Transmission
Volume120
Issue number5
DOIs
StatePublished - May 2013

Fingerprint

Parkinson Disease
ROC Curve
Nerve Fibers
Retinal Neurons
Eye Diseases
Optical Coherence Tomography
Ganglia
Retina
Healthy Volunteers
Oxidative Stress
Sensitivity and Specificity
Research

Keywords

  • Dopaminergic neurons
  • Foveal avascular zone (FAZ)
  • Optical coherence tomography (OCT)
  • Parkinson disease (PD)
  • Receiver operating characteristics (ROC)
  • Retinal foveal pit

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Spund, B., Ding, Y., Liu, T., Selesnick, I., Glazman, S., Shrier, E. M., & Bodis-Wollner, I. (2013). Remodeling of the fovea in Parkinson disease. Journal of Neural Transmission, 120(5), 745-753. https://doi.org/10.1007/s00702-012-0909-5

Remodeling of the fovea in Parkinson disease. / Spund, B.; Ding, Y.; Liu, T.; Selesnick, Ivan; Glazman, S.; Shrier, E. M.; Bodis-Wollner, I.

In: Journal of Neural Transmission, Vol. 120, No. 5, 05.2013, p. 745-753.

Research output: Contribution to journalArticle

Spund, B, Ding, Y, Liu, T, Selesnick, I, Glazman, S, Shrier, EM & Bodis-Wollner, I 2013, 'Remodeling of the fovea in Parkinson disease', Journal of Neural Transmission, vol. 120, no. 5, pp. 745-753. https://doi.org/10.1007/s00702-012-0909-5
Spund, B. ; Ding, Y. ; Liu, T. ; Selesnick, Ivan ; Glazman, S. ; Shrier, E. M. ; Bodis-Wollner, I. / Remodeling of the fovea in Parkinson disease. In: Journal of Neural Transmission. 2013 ; Vol. 120, No. 5. pp. 745-753.
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