Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations

Natalia L. Komarova, Daniela Anghelina, Igor Voznesensky, Benjamin Trinité, David N. Levy, Dominik Wodarz

Research output: Contribution to journalArticle

Abstract

Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.

Original languageEnglish (US)
Article number1049
JournalBiology Letters
Volume9
Issue number1
DOIs
StatePublished - Feb 23 2013

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synaptic transmission
Health Services Needs and Demand
virus transmission
Human immunodeficiency virus 1
Synaptic Transmission
HIV-1
Viruses
cells
viruses
Population Growth
Human immunodeficiency virus
synapse
Synapses
Theoretical Models
mathematical models
HIV
Growth
Infection
infection

Keywords

  • Human immunodeficiency virus
  • Mathematical model
  • Virological synapse

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations. / Komarova, Natalia L.; Anghelina, Daniela; Voznesensky, Igor; Trinité, Benjamin; Levy, David N.; Wodarz, Dominik.

In: Biology Letters, Vol. 9, No. 1, 1049, 23.02.2013.

Research output: Contribution to journalArticle

Komarova, Natalia L. ; Anghelina, Daniela ; Voznesensky, Igor ; Trinité, Benjamin ; Levy, David N. ; Wodarz, Dominik. / Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations. In: Biology Letters. 2013 ; Vol. 9, No. 1.
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