Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations

Natalia L. Komarova, Daniela Anghelina, Igor Voznesensky, Benjamin Trinité, David N. Levy, Dominik Wodarz

Research output: Contribution to journalArticle

Abstract

Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.

Original languageEnglish (US)
Article number20121049
JournalBiology Letters
Volume9
Issue number1
DOIs
StatePublished - Feb 23 2013

Keywords

  • Human immunodeficiency virus
  • Mathematical model
  • Virological synapse

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations'. Together they form a unique fingerprint.

  • Cite this