Relationship of destructive periodontal disease to the acute-phase response

Ronald Craig, Julie Yip, Man Ki So, Robert Boylan, Sigmund S. Socransky, Anne D. Haffajee

Research output: Contribution to journalArticle

Abstract

Background: Destructive periodontal diseases have been associated with an increased risk of atherosclerotic complications; however, the potential mechanisms are yet to be defined. Inflammation plays a central role in atherosclerosis since C-reactive protein (CRP), an acute-phase protein monitored as a marker of inflammatory status, has been identified as a major risk factor for atherosclerotic complications. Recent reports that destructive periodontal diseases can increase CRP values present the possibility that the acute-phase response may link these 2 disease processes. The objective of the present investigation was to determine the effect of destructive periodontal disease status, severity, and progression on components of the acute-phase response in an urban minority population. Methods: Clinical measurements recorded included probing depth, attachment level, gingival erythema, bleeding upon probing, suppuration, and plaque. Disease progression was defined as a >2 mm loss of attachment 2 months post-baseline. Serum antibody was measured by enzyme-linked immunosorbent assay. CRP was measured using a high-sensitivity CRP (hsCRP) assay. A commercial laboratory measured serum glucose (non-fasting), albumin, cholesterol, high-density lipoprotein (HDL), triglycerides, low-density lipoprotein (LDL), and iron. Results: Increased serum IgG antibody to Porphyromonas gingivalis, but not to 5 other species, was associated with periodontal disease status, increased severity, and progression as were age, male gender, and smoking. Cholesterol and LDL were increased in disease, and HDL and iron were increased in health. hsCRP, glucose, and cholesterol increased with disease progression. By regression analysis, IgG antibody to P. gingivalis correlated with age, probing depth, and hsCRP, and negatively correlated with albumin and iron. By logistic regression, subjects who experienced multiple sites of disease progression and elevated antibody to P. gingivalis increased the odds ratio of hsCRP >2.08 mg/l by 14.1 and 5.6, respectively. Conclusion: These results suggest that destructive periodontal disease and disease progression are associated with changes in serum components consistent with an acute-phase response.

Original languageEnglish (US)
Pages (from-to)1007-1016
Number of pages10
JournalJournal of Periodontology
Volume74
Issue number7
DOIs
StatePublished - Jul 1 2003

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Acute-Phase Reaction
Periodontal Diseases
C-Reactive Protein
Porphyromonas gingivalis
Disease Progression
Iron
Antibodies
Serum
Albumins
Immunoglobulin G
Glucose
Urban Population
Suppuration
Acute-Phase Proteins
HDL Lipoproteins
Erythema
LDL Cholesterol
HDL Cholesterol
Atherosclerosis
Logistic Models

Keywords

  • Acute phase reactions
  • Antibodies, IgG
  • Atherosclerosis
  • C-reactive protein
  • Periodontal diseases/complications
  • Risk factors

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Relationship of destructive periodontal disease to the acute-phase response. / Craig, Ronald; Yip, Julie; So, Man Ki; Boylan, Robert; Socransky, Sigmund S.; Haffajee, Anne D.

In: Journal of Periodontology, Vol. 74, No. 7, 01.07.2003, p. 1007-1016.

Research output: Contribution to journalArticle

Craig, Ronald ; Yip, Julie ; So, Man Ki ; Boylan, Robert ; Socransky, Sigmund S. ; Haffajee, Anne D. / Relationship of destructive periodontal disease to the acute-phase response. In: Journal of Periodontology. 2003 ; Vol. 74, No. 7. pp. 1007-1016.
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