Relationship between CT intensity, micro-architecture and mechanical properties of porcine vertebral cancellous bone

Jeremy Teo, Kuan Ming Si-Hoe, Justin E L Keh, Swee Hin Teoh

    Research output: Contribution to journalArticle

    Abstract

    Background. In vivo assessment of bone density is insufficient for the evaluation of osteoporosis in patients. A more complete diagnostic tool for the determination of bone quality is needed. Micro-computed tomography imaging allows a non-destructive method for evaluating cancellous bone micro-architecture. However, lengthened exposure to ionizing radiation prevents patients to be imaged by such a system. The aim for this study was to elucidate the relationships between image intensity (of Hounsfield units), cancellous bone micro-architecture and mechanical properties. Methods. Using pig vertebral cancellous bone, the bone specimens were imaged using clinical and micro-computed tomography scanners and subsequently subjected to uniaxial compression testing. Results. Results indicate that micro-architecture can be predicted using clinical image intensity. Micro-architectural parameters relevant to osteoporosis study, such as percent bone volume, trabecular bone pattern factor, structure model index, trabecular thickness and trabecular separation have shown significant correlation with R2 values of 0.83, 0.80, 0.70, 0.72, and 0.54, respectively, when correlated to Hounsfield units. In addition, the correlation of mechanical properties (E, σ yield, and σult) in the superior-inferior direction (the primary loading direction), to micro-architecture parameters has also been good (R2 > 0.5) for all except tissue volume, tissue surface and degree of anisotropy. Interpretation. This proves that the predictive power of bone strength and stiffness was improved with the combination of bone density and micro-architecture information. This work supports the prediction of micro-architecture using current clinical computed tomography imaging technology.

    Original languageEnglish (US)
    Pages (from-to)235-244
    Number of pages10
    JournalClinical Biomechanics
    Volume21
    Issue number3
    DOIs
    StatePublished - Mar 1 2006

    Fingerprint

    Swine
    Bone and Bones
    Bone Density
    Osteoporosis
    Tomography
    X-Ray Computed Tomography Scanners
    Anisotropy
    Ionizing Radiation
    Technology
    Cancellous Bone
    Direction compound

    Keywords

    • Bone mechanical properties
    • Bone micro-architecture
    • Cancellous bone
    • Micro-CT
    • Porcine bone

    ASJC Scopus subject areas

    • Orthopedics and Sports Medicine

    Cite this

    Relationship between CT intensity, micro-architecture and mechanical properties of porcine vertebral cancellous bone. / Teo, Jeremy; Si-Hoe, Kuan Ming; Keh, Justin E L; Teoh, Swee Hin.

    In: Clinical Biomechanics, Vol. 21, No. 3, 01.03.2006, p. 235-244.

    Research output: Contribution to journalArticle

    Teo, Jeremy ; Si-Hoe, Kuan Ming ; Keh, Justin E L ; Teoh, Swee Hin. / Relationship between CT intensity, micro-architecture and mechanical properties of porcine vertebral cancellous bone. In: Clinical Biomechanics. 2006 ; Vol. 21, No. 3. pp. 235-244.
    @article{f4cd5e521f1545cba4a00b3750c40444,
    title = "Relationship between CT intensity, micro-architecture and mechanical properties of porcine vertebral cancellous bone",
    abstract = "Background. In vivo assessment of bone density is insufficient for the evaluation of osteoporosis in patients. A more complete diagnostic tool for the determination of bone quality is needed. Micro-computed tomography imaging allows a non-destructive method for evaluating cancellous bone micro-architecture. However, lengthened exposure to ionizing radiation prevents patients to be imaged by such a system. The aim for this study was to elucidate the relationships between image intensity (of Hounsfield units), cancellous bone micro-architecture and mechanical properties. Methods. Using pig vertebral cancellous bone, the bone specimens were imaged using clinical and micro-computed tomography scanners and subsequently subjected to uniaxial compression testing. Results. Results indicate that micro-architecture can be predicted using clinical image intensity. Micro-architectural parameters relevant to osteoporosis study, such as percent bone volume, trabecular bone pattern factor, structure model index, trabecular thickness and trabecular separation have shown significant correlation with R2 values of 0.83, 0.80, 0.70, 0.72, and 0.54, respectively, when correlated to Hounsfield units. In addition, the correlation of mechanical properties (E, σ yield, and σult) in the superior-inferior direction (the primary loading direction), to micro-architecture parameters has also been good (R2 > 0.5) for all except tissue volume, tissue surface and degree of anisotropy. Interpretation. This proves that the predictive power of bone strength and stiffness was improved with the combination of bone density and micro-architecture information. This work supports the prediction of micro-architecture using current clinical computed tomography imaging technology.",
    keywords = "Bone mechanical properties, Bone micro-architecture, Cancellous bone, Micro-CT, Porcine bone",
    author = "Jeremy Teo and Si-Hoe, {Kuan Ming} and Keh, {Justin E L} and Teoh, {Swee Hin}",
    year = "2006",
    month = "3",
    day = "1",
    doi = "10.1016/j.clinbiomech.2005.11.001",
    language = "English (US)",
    volume = "21",
    pages = "235--244",
    journal = "Clinical Biomechanics",
    issn = "0268-0033",
    publisher = "Elsevier Limited",
    number = "3",

    }

    TY - JOUR

    T1 - Relationship between CT intensity, micro-architecture and mechanical properties of porcine vertebral cancellous bone

    AU - Teo, Jeremy

    AU - Si-Hoe, Kuan Ming

    AU - Keh, Justin E L

    AU - Teoh, Swee Hin

    PY - 2006/3/1

    Y1 - 2006/3/1

    N2 - Background. In vivo assessment of bone density is insufficient for the evaluation of osteoporosis in patients. A more complete diagnostic tool for the determination of bone quality is needed. Micro-computed tomography imaging allows a non-destructive method for evaluating cancellous bone micro-architecture. However, lengthened exposure to ionizing radiation prevents patients to be imaged by such a system. The aim for this study was to elucidate the relationships between image intensity (of Hounsfield units), cancellous bone micro-architecture and mechanical properties. Methods. Using pig vertebral cancellous bone, the bone specimens were imaged using clinical and micro-computed tomography scanners and subsequently subjected to uniaxial compression testing. Results. Results indicate that micro-architecture can be predicted using clinical image intensity. Micro-architectural parameters relevant to osteoporosis study, such as percent bone volume, trabecular bone pattern factor, structure model index, trabecular thickness and trabecular separation have shown significant correlation with R2 values of 0.83, 0.80, 0.70, 0.72, and 0.54, respectively, when correlated to Hounsfield units. In addition, the correlation of mechanical properties (E, σ yield, and σult) in the superior-inferior direction (the primary loading direction), to micro-architecture parameters has also been good (R2 > 0.5) for all except tissue volume, tissue surface and degree of anisotropy. Interpretation. This proves that the predictive power of bone strength and stiffness was improved with the combination of bone density and micro-architecture information. This work supports the prediction of micro-architecture using current clinical computed tomography imaging technology.

    AB - Background. In vivo assessment of bone density is insufficient for the evaluation of osteoporosis in patients. A more complete diagnostic tool for the determination of bone quality is needed. Micro-computed tomography imaging allows a non-destructive method for evaluating cancellous bone micro-architecture. However, lengthened exposure to ionizing radiation prevents patients to be imaged by such a system. The aim for this study was to elucidate the relationships between image intensity (of Hounsfield units), cancellous bone micro-architecture and mechanical properties. Methods. Using pig vertebral cancellous bone, the bone specimens were imaged using clinical and micro-computed tomography scanners and subsequently subjected to uniaxial compression testing. Results. Results indicate that micro-architecture can be predicted using clinical image intensity. Micro-architectural parameters relevant to osteoporosis study, such as percent bone volume, trabecular bone pattern factor, structure model index, trabecular thickness and trabecular separation have shown significant correlation with R2 values of 0.83, 0.80, 0.70, 0.72, and 0.54, respectively, when correlated to Hounsfield units. In addition, the correlation of mechanical properties (E, σ yield, and σult) in the superior-inferior direction (the primary loading direction), to micro-architecture parameters has also been good (R2 > 0.5) for all except tissue volume, tissue surface and degree of anisotropy. Interpretation. This proves that the predictive power of bone strength and stiffness was improved with the combination of bone density and micro-architecture information. This work supports the prediction of micro-architecture using current clinical computed tomography imaging technology.

    KW - Bone mechanical properties

    KW - Bone micro-architecture

    KW - Cancellous bone

    KW - Micro-CT

    KW - Porcine bone

    UR - http://www.scopus.com/inward/record.url?scp=31544441607&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=31544441607&partnerID=8YFLogxK

    U2 - 10.1016/j.clinbiomech.2005.11.001

    DO - 10.1016/j.clinbiomech.2005.11.001

    M3 - Article

    VL - 21

    SP - 235

    EP - 244

    JO - Clinical Biomechanics

    JF - Clinical Biomechanics

    SN - 0268-0033

    IS - 3

    ER -