Regulatory gene expressions in the ascidian ventral sensory vesicle: Evolutionary relationships with the vertebrate hypothalamus

Frédéric Moret, Lionel Christiaen, Carole Deyts, Maryline Blin, Philippe Vernier, Jean Stéphane Joly

Research output: Contribution to journalArticle

Abstract

In extant chordates, the overall patterning along the anteroposterior and dorsoventral axes of the neural tube is remarkably conserved. It has thus been proposed that four domains corresponding to the vertebrate presumptive forebrain, midbrain-hindbrain transition, hindbrain, and spinal cord were already present in the common chordate ancestor. To obtain insights on the evolution of the patterning of the anterior neural tube, we performed a study aimed at characterizing the expression of regulatory genes in the sensory vesicle of Ciona intestinalis, the anteriormost part of the central nervous system (CNS) related to the vertebrate forebrain, at tailbud stages. Selected genes encoded primarily for homologues of transcription factors involved in vertebrate forebrain patterning. Seven of these genes were expressed in the ventral sensory vesicle. A prominent feature of these ascidian genes is their restricted and complementary domains of expression at tailbud stages. These patterning markers thus refine the map of the developing sensory vesicle. Furthermore, they allow us to propose that a large part of the ventral and lateral sensory vesicle consists in a patterning domain corresponding to the vertebrate presumptive hypothalamus.

Original languageEnglish (US)
Pages (from-to)567-579
Number of pages13
JournalDevelopmental Biology
Volume277
Issue number2
DOIs
StatePublished - Jan 15 2005

Fingerprint

Urochordata
Regulator Genes
Hypothalamus
Vertebrates
Prosencephalon
Chordata
Gene Expression
Rhombencephalon
Neural Tube
Ciona intestinalis
Genes
Mesencephalon
Spinal Cord
Transcription Factors
Central Nervous System

Keywords

  • Ascidian ventral sensory vesicle
  • Hypothalamus
  • Regulatory gene expressions

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Regulatory gene expressions in the ascidian ventral sensory vesicle : Evolutionary relationships with the vertebrate hypothalamus. / Moret, Frédéric; Christiaen, Lionel; Deyts, Carole; Blin, Maryline; Vernier, Philippe; Joly, Jean Stéphane.

In: Developmental Biology, Vol. 277, No. 2, 15.01.2005, p. 567-579.

Research output: Contribution to journalArticle

Moret, Frédéric ; Christiaen, Lionel ; Deyts, Carole ; Blin, Maryline ; Vernier, Philippe ; Joly, Jean Stéphane. / Regulatory gene expressions in the ascidian ventral sensory vesicle : Evolutionary relationships with the vertebrate hypothalamus. In: Developmental Biology. 2005 ; Vol. 277, No. 2. pp. 567-579.
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