Regulation of the X chromosomes in Caenorhabditis elegans

Susan Strome, William G. Kelly, Sevinc Ercan, Jason D. Lieb

Research output: Contribution to journalArticle

Abstract

Dosage compensation, which regulates the expression of genes residing on the sex chromosomes, has provided valuable insights into chromatin-based mechanisms of gene regulation. The nematode Caenorhabditis elegans has adopted various strategies to down-regulate and even nearly silence the X chromosomes. This article discusses the different chromatin-based strategies used in somatic tissues and in the germline to modulate gene expression from the C. elegans X chromosomes and compares these strategies to those used by other organisms to cope with similar X-chromosome dosage differences.

Original languageEnglish (US)
JournalCold Spring Harbor perspectives in biology
Volume6
Issue number3
DOIs
StatePublished - Mar 2014

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Caenorhabditis elegans
X Chromosome
Chromosomes
Gene expression
Chromatin
Gene Expression
Sex Chromosomes
Down-Regulation
Genes
Tissue

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Regulation of the X chromosomes in Caenorhabditis elegans. / Strome, Susan; Kelly, William G.; Ercan, Sevinc; Lieb, Jason D.

In: Cold Spring Harbor perspectives in biology, Vol. 6, No. 3, 03.2014.

Research output: Contribution to journalArticle

Strome, Susan ; Kelly, William G. ; Ercan, Sevinc ; Lieb, Jason D. / Regulation of the X chromosomes in Caenorhabditis elegans. In: Cold Spring Harbor perspectives in biology. 2014 ; Vol. 6, No. 3.
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