Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins

Laurent M. Dejean, Sonia Martinez-Caballero, Stephen Manon, Kathleen W. Kinnally

Research output: Contribution to journalArticle

Abstract

Programmed cell death or apoptosis is central to many physiological processes and pathological conditions such as organogenesis, tissue homeostasis, cancer, and neurodegenerative diseases. Bcl-2 family proteins tightly control this cell death program by regulating the permeabilization of the mitochondrial outer membrane and, hence, the release of cytochrome c and other pro-apoptotic factors. Control of the formation of the mitochondrial apoptosis-induced channel, or MAC, is central to the regulation of apoptosis by Bcl-2 family proteins. MAC is detected early in apoptosis by patch clamping the mitochondrial outer membrane. The focus of this review is on the regulation of MAC activity by Bcl-2 family proteins. The role of MAC as the putative cytochrome c release channel during early apoptosis and insights concerning its molecular composition are also discussed.

Original languageEnglish (US)
Pages (from-to)191-201
Number of pages11
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1762
Issue number2
DOIs
StatePublished - Feb 2006

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Apoptosis
Mitochondrial Membranes
Cytochromes c
Proteins
Cell Death
Physiological Phenomena
Organogenesis
Constriction
Neurodegenerative Diseases
Homeostasis
U 78517F
Neoplasms

Keywords

  • Apoptosis
  • Bax
  • Bcl-2
  • MAC
  • Mitochondrial apoptosis-induced channel
  • Patch clamp

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Biophysics

Cite this

Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins. / Dejean, Laurent M.; Martinez-Caballero, Sonia; Manon, Stephen; Kinnally, Kathleen W.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1762, No. 2, 02.2006, p. 191-201.

Research output: Contribution to journalArticle

Dejean, Laurent M. ; Martinez-Caballero, Sonia ; Manon, Stephen ; Kinnally, Kathleen W. / Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins. In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 2006 ; Vol. 1762, No. 2. pp. 191-201.
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