Regulation of inhibitory synapse function in the developing auditory CNS

Dan Sanes, Emma C. Sarro, Anne E. Takesian, Chiye Aoki, Vibhakar C. Kotak

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Auditory processing requires a balanced participation of synaptic inhibition and excitation. This balance is achieved during development, in part, through the refinement of inhibitory connections and the regulation of inhibitory functional properties. Here, we make the case that spontaneous and experience-driven activity contributes to these maturational events in the auditory brainstem and cortex. Using brain slice preparations, we selectively assessed the physiology and plasticity of central inhibitory transmission. Together, the results demonstrate that inhibitory synapse function is regulated at every central location examined. The sites of regulation involve presynaptic factors such as transmitter synthesis and release properties, as well as postsynaptic factors such as receptor subunit kinetics, KCC2 function, and long-term depression. We propose that reduced inhibitory strength following disuse is due to delayed development, and this may contribute the enhanced excitability.

Original languageEnglish (US)
Title of host publicationDevelopmental Plasticity of Inhibitory Circuitry
PublisherSpringer US
Pages43-69
Number of pages27
ISBN (Print)9781441912435, 9781441912428
DOIs
StatePublished - 2010

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Auditory Cortex
Synapses
Brain Stem
Physiology
Brain
Plasticity
Transmitters
Kinetics
Processing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Neuroscience(all)

Cite this

Sanes, D., Sarro, E. C., Takesian, A. E., Aoki, C., & Kotak, V. C. (2010). Regulation of inhibitory synapse function in the developing auditory CNS. In Developmental Plasticity of Inhibitory Circuitry (pp. 43-69). Springer US. https://doi.org/10.1007/978-1-4419-1243-5_4

Regulation of inhibitory synapse function in the developing auditory CNS. / Sanes, Dan; Sarro, Emma C.; Takesian, Anne E.; Aoki, Chiye; Kotak, Vibhakar C.

Developmental Plasticity of Inhibitory Circuitry. Springer US, 2010. p. 43-69.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sanes, D, Sarro, EC, Takesian, AE, Aoki, C & Kotak, VC 2010, Regulation of inhibitory synapse function in the developing auditory CNS. in Developmental Plasticity of Inhibitory Circuitry. Springer US, pp. 43-69. https://doi.org/10.1007/978-1-4419-1243-5_4
Sanes D, Sarro EC, Takesian AE, Aoki C, Kotak VC. Regulation of inhibitory synapse function in the developing auditory CNS. In Developmental Plasticity of Inhibitory Circuitry. Springer US. 2010. p. 43-69 https://doi.org/10.1007/978-1-4419-1243-5_4
Sanes, Dan ; Sarro, Emma C. ; Takesian, Anne E. ; Aoki, Chiye ; Kotak, Vibhakar C. / Regulation of inhibitory synapse function in the developing auditory CNS. Developmental Plasticity of Inhibitory Circuitry. Springer US, 2010. pp. 43-69
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