Regulation of cyclin D1 gene expression

Ini Isabée Witzel, Li Fang Koh, Neil D. Perkins

Research output: Contribution to journalArticle

Abstract

Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. In different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas their disregulation can contribute to overexpression of cyclin D1 in tumorigenesis. Here, we discuss the ability of the NF-κB (nuclear factor κB)/IKK [IκB (inhibitor of NF-κB) kinase] pathways to regulate cyclin D1 gene transcription and also consider the newly discovered role of the SNARP (SNIP1/SkIP-associated RNA processing) complex as a co-transcriptional regulator of cyclin D1 RNA stability.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalBiochemical Society Transactions
Volume38
Issue number1
DOIs
StatePublished - Feb 17 2010

Keywords

  • Cyclin D1
  • Nuclear factor κB (NF-κB)
  • RNA processing
  • Smad nuclear interacting protein 1 (SNIP1)
  • Transcription

ASJC Scopus subject areas

  • Biochemistry

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  • Cite this

    Witzel, I. I., Koh, L. F., & Perkins, N. D. (2010). Regulation of cyclin D1 gene expression. Biochemical Society Transactions, 38(1), 217-222. https://doi.org/10.1042/BST0380217