Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog

Jhumku D. Kohtz, Darren P. Baker, Giorgio Corte, Gordon Fishell

    Research output: Contribution to journalArticle

    Abstract

    The cortex and basal ganglia are the major structures of the adult brain derived from the embryonic telencephalon. Two morphologically distinct regions of the basal ganglia are evident within the mature ventral telencephalon, the globus pallidus medially, and the striatum, which is positioned between the globus pallidus and the cortex. Deletion of the Sonic Hedgehog gene in mice indicates that this secreted signaling molecule is vital for the generation of both these ventral telencephalic experiments showed that Sonic differentiation of ventral neurons characteristic of the medial ganglionic eminence, the embryonic structure which gives rise to the globus pallidus. In this paper, we show that later in development, Sonic Hedgehog induces ventral neurons with patterns of gene expression characteristic of the lateral ganglionic eminence. This is the embryonic structure from which the striatum is derived. These results suggest that temporally regulated changes in Sonic Hedgehog responsiveness are integral in the sequential induction of basal telencephalic structures.

    Original languageEnglish (US)
    Pages (from-to)5079-5089
    Number of pages11
    JournalDevelopment
    Volume125
    Issue number24
    StatePublished - Dec 1 1998

    Fingerprint

    Telencephalon
    Hedgehogs
    Globus Pallidus
    Basal Ganglia
    Embryonic Structures
    Neurons
    Median Eminence
    Gene Expression
    Brain
    Genes

    Keywords

    • Neurogenesis
    • Rat
    • Sonic Hedgehog
    • Telencephalon

    ASJC Scopus subject areas

    • Molecular Biology
    • Developmental Biology

    Cite this

    Kohtz, J. D., Baker, D. P., Corte, G., & Fishell, G. (1998). Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog. Development, 125(24), 5079-5089.

    Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog. / Kohtz, Jhumku D.; Baker, Darren P.; Corte, Giorgio; Fishell, Gordon.

    In: Development, Vol. 125, No. 24, 01.12.1998, p. 5079-5089.

    Research output: Contribution to journalArticle

    Kohtz, JD, Baker, DP, Corte, G & Fishell, G 1998, 'Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog', Development, vol. 125, no. 24, pp. 5079-5089.
    Kohtz, Jhumku D. ; Baker, Darren P. ; Corte, Giorgio ; Fishell, Gordon. / Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog. In: Development. 1998 ; Vol. 125, No. 24. pp. 5079-5089.
    @article{2133b124b9014295ba232f2eac6b5091,
    title = "Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog",
    abstract = "The cortex and basal ganglia are the major structures of the adult brain derived from the embryonic telencephalon. Two morphologically distinct regions of the basal ganglia are evident within the mature ventral telencephalon, the globus pallidus medially, and the striatum, which is positioned between the globus pallidus and the cortex. Deletion of the Sonic Hedgehog gene in mice indicates that this secreted signaling molecule is vital for the generation of both these ventral telencephalic experiments showed that Sonic differentiation of ventral neurons characteristic of the medial ganglionic eminence, the embryonic structure which gives rise to the globus pallidus. In this paper, we show that later in development, Sonic Hedgehog induces ventral neurons with patterns of gene expression characteristic of the lateral ganglionic eminence. This is the embryonic structure from which the striatum is derived. These results suggest that temporally regulated changes in Sonic Hedgehog responsiveness are integral in the sequential induction of basal telencephalic structures.",
    keywords = "Neurogenesis, Rat, Sonic Hedgehog, Telencephalon",
    author = "Kohtz, {Jhumku D.} and Baker, {Darren P.} and Giorgio Corte and Gordon Fishell",
    year = "1998",
    month = "12",
    day = "1",
    language = "English (US)",
    volume = "125",
    pages = "5079--5089",
    journal = "Development (Cambridge)",
    issn = "0950-1991",
    publisher = "Company of Biologists Ltd",
    number = "24",

    }

    TY - JOUR

    T1 - Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog

    AU - Kohtz, Jhumku D.

    AU - Baker, Darren P.

    AU - Corte, Giorgio

    AU - Fishell, Gordon

    PY - 1998/12/1

    Y1 - 1998/12/1

    N2 - The cortex and basal ganglia are the major structures of the adult brain derived from the embryonic telencephalon. Two morphologically distinct regions of the basal ganglia are evident within the mature ventral telencephalon, the globus pallidus medially, and the striatum, which is positioned between the globus pallidus and the cortex. Deletion of the Sonic Hedgehog gene in mice indicates that this secreted signaling molecule is vital for the generation of both these ventral telencephalic experiments showed that Sonic differentiation of ventral neurons characteristic of the medial ganglionic eminence, the embryonic structure which gives rise to the globus pallidus. In this paper, we show that later in development, Sonic Hedgehog induces ventral neurons with patterns of gene expression characteristic of the lateral ganglionic eminence. This is the embryonic structure from which the striatum is derived. These results suggest that temporally regulated changes in Sonic Hedgehog responsiveness are integral in the sequential induction of basal telencephalic structures.

    AB - The cortex and basal ganglia are the major structures of the adult brain derived from the embryonic telencephalon. Two morphologically distinct regions of the basal ganglia are evident within the mature ventral telencephalon, the globus pallidus medially, and the striatum, which is positioned between the globus pallidus and the cortex. Deletion of the Sonic Hedgehog gene in mice indicates that this secreted signaling molecule is vital for the generation of both these ventral telencephalic experiments showed that Sonic differentiation of ventral neurons characteristic of the medial ganglionic eminence, the embryonic structure which gives rise to the globus pallidus. In this paper, we show that later in development, Sonic Hedgehog induces ventral neurons with patterns of gene expression characteristic of the lateral ganglionic eminence. This is the embryonic structure from which the striatum is derived. These results suggest that temporally regulated changes in Sonic Hedgehog responsiveness are integral in the sequential induction of basal telencephalic structures.

    KW - Neurogenesis

    KW - Rat

    KW - Sonic Hedgehog

    KW - Telencephalon

    UR - http://www.scopus.com/inward/record.url?scp=0032427449&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0032427449&partnerID=8YFLogxK

    M3 - Article

    VL - 125

    SP - 5079

    EP - 5089

    JO - Development (Cambridge)

    JF - Development (Cambridge)

    SN - 0950-1991

    IS - 24

    ER -