Regional characterization of longitudinal DT-MRI to study white matter maturation of the early developing brain

Neda Sadeghi, Marcel Prastawa, P. Thomas Fletcher, Jason Wolff, John H. Gilmore, Guido Gerig

    Research output: Contribution to journalArticle

    Abstract

    The human brain undergoes rapid and dynamic development early in life. Assessment of brain growth patterns relevant to neurological disorders and disease requires a normative population model of growth and variability in order to evaluate deviation from typical development. In this paper, we focus on maturation of brain white matter as shown in diffusion tensor MRI (DT-MRI), measured by fractional anisotropy (FA), mean diffusivity (MD), as well as axial and radial diffusivities (AD, RD). We present a novel methodology to model temporal changes of white matter diffusion from longitudinal DT-MRI data taken at discrete time points. Our proposed framework combines nonlinear modeling of trajectories of individual subjects, population analysis, and testing for regional differences in growth pattern. We first perform deformable mapping of longitudinal DT-MRI of healthy infants imaged at birth, 1 year, and 2 years of age, into a common unbiased atlas. An existing template of labeled white matter regions is registered to this atlas to define anatomical regions of interest. Diffusivity properties of these regions, presented over time, serve as input to the longitudinal characterization of changes. We use non-linear mixed effect (NLME) modeling where temporal change is described by the Gompertz function. The Gompertz growth function uses intuitive parameters related to delay, rate of change, and expected asymptotic value; all descriptive measures which can answer clinical questions related to quantitative analysis of growth patterns. Results suggest that our proposed framework provides descriptive and quantitative information on growth trajectories that can be interpreted by clinicians using natural language terms that describe growth. Statistical analysis of regional differences between anatomical regions which are known to mature differently demonstrates the potential of the proposed method for quantitative assessment of brain growth and differences thereof. This will eventually lead to a prediction of white matter diffusion properties and associated cognitive development at later stages given imaging data at early stages.

    Original languageEnglish (US)
    Pages (from-to)236-247
    Number of pages12
    JournalNeuroImage
    Volume68
    DOIs
    StatePublished - Mar 2013

    Fingerprint

    Diffusion Magnetic Resonance Imaging
    Brain
    Growth
    Atlases
    Population Growth
    Anisotropy
    White Matter
    Nervous System Diseases
    Language
    Parturition
    Population

    Keywords

    • DTI
    • Early brain development
    • Longitudinal brain imaging
    • Nonlinear mixed effect modeling

    ASJC Scopus subject areas

    • Cognitive Neuroscience
    • Neurology

    Cite this

    Regional characterization of longitudinal DT-MRI to study white matter maturation of the early developing brain. / Sadeghi, Neda; Prastawa, Marcel; Fletcher, P. Thomas; Wolff, Jason; Gilmore, John H.; Gerig, Guido.

    In: NeuroImage, Vol. 68, 03.2013, p. 236-247.

    Research output: Contribution to journalArticle

    Sadeghi, Neda ; Prastawa, Marcel ; Fletcher, P. Thomas ; Wolff, Jason ; Gilmore, John H. ; Gerig, Guido. / Regional characterization of longitudinal DT-MRI to study white matter maturation of the early developing brain. In: NeuroImage. 2013 ; Vol. 68. pp. 236-247.
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