Recognition of neutral species with synthetic receptors

Heidi Chen, Warren S. Weiner, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

The design of synthetic receptors for neutral molecules is an area of intense current interest. The area has grown from early work on cyclodextrin or single crown ether complexation to encompass a wide array of receptor shapes and structures. Furthermore, the range of substrate selectivities has increased from simple aromatic or metal ion substrates to include key biological components such as peptides and carbohydrates. Recent advances have included the application of split bead combinatorial methods for the identification of receptors for oligopeptides, the design of self-assembling spherical receptors, the use of multiple hydrogen bonding groups for carboxylic acid and carbohydrate recognition and the achievement of impressive catalytic effects with synthetic receptors.

Original languageEnglish (US)
Pages (from-to)458-466
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume1
Issue number4
StatePublished - Dec 1997

Fingerprint

Artificial Receptors
Carbohydrates
Crown Ethers
Oligopeptides
Cyclodextrins
Substrates
Hydrogen Bonding
Carboxylic Acids
Complexation
Metal ions
Hydrogen bonds
Metals
Ions
Peptides
Molecules

ASJC Scopus subject areas

  • Biochemistry

Cite this

Recognition of neutral species with synthetic receptors. / Chen, Heidi; Weiner, Warren S.; Hamilton, Andrew.

In: Current Opinion in Chemical Biology, Vol. 1, No. 4, 12.1997, p. 458-466.

Research output: Contribution to journalArticle

Chen, Heidi ; Weiner, Warren S. ; Hamilton, Andrew. / Recognition of neutral species with synthetic receptors. In: Current Opinion in Chemical Biology. 1997 ; Vol. 1, No. 4. pp. 458-466.
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