Reaction of the octahedral antitumor complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine

Sabina Cauci, Paolo Viglino, Gennaro Esposito, Franco Quadrifoglio

    Research output: Contribution to journalArticle

    Abstract

    The reaction of the antitumor octahedral complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine leads to the reversible formation of two diastereoisomeric monoadducts and one biadduct. This shows that it is possible to accomodate two purine bases in a cis configuration in an octahedral transition metal complex which exhibits antiblastic activity. All the product compounds are characterized by a guanine moiety coordination via the N7 atom. A marked decrease (about two pK units) is observed for the N1H pKa of the coordinated guanine moieties. The reversibility of the monodentate binding could explain the low toxicity of the ruthenium(II) complexes.

    Original languageEnglish (US)
    Pages (from-to)739-751
    Number of pages13
    JournalJournal of Inorganic Biochemistry
    Volume43
    Issue number4
    DOIs
    StatePublished - Jan 1 1991

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    Guanine
    Ruthenium
    Coordination Complexes
    Transition metals
    Toxicity
    Atoms
    dichlorotetrakis(dimethyl sulfoxide)ruthenium II
    purine

    ASJC Scopus subject areas

    • Biochemistry
    • Inorganic Chemistry

    Cite this

    Reaction of the octahedral antitumor complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine. / Cauci, Sabina; Viglino, Paolo; Esposito, Gennaro; Quadrifoglio, Franco.

    In: Journal of Inorganic Biochemistry, Vol. 43, No. 4, 01.01.1991, p. 739-751.

    Research output: Contribution to journalArticle

    Cauci, Sabina ; Viglino, Paolo ; Esposito, Gennaro ; Quadrifoglio, Franco. / Reaction of the octahedral antitumor complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine. In: Journal of Inorganic Biochemistry. 1991 ; Vol. 43, No. 4. pp. 739-751.
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