Reaction of the octahedral antitumor complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine

Sabina Cauci, Paolo Viglino, Gennaro Esposito, Franco Quadrifoglio

Research output: Contribution to journalArticle

Abstract

The reaction of the antitumor octahedral complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine leads to the reversible formation of two diastereoisomeric monoadducts and one biadduct. This shows that it is possible to accomodate two purine bases in a cis configuration in an octahedral transition metal complex which exhibits antiblastic activity. All the product compounds are characterized by a guanine moiety coordination via the N7 atom. A marked decrease (about two pK units) is observed for the N1H pKa of the coordinated guanine moieties. The reversibility of the monodentate binding could explain the low toxicity of the ruthenium(II) complexes.

Original languageEnglish (US)
Pages (from-to)739-751
Number of pages13
JournalJournal of Inorganic Biochemistry
Volume43
Issue number4
DOIs
StatePublished - Jan 1 1991

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Guanine
Ruthenium
Coordination Complexes
Transition metals
Toxicity
Atoms
dichlorotetrakis(dimethyl sulfoxide)ruthenium II
purine

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Reaction of the octahedral antitumor complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine. / Cauci, Sabina; Viglino, Paolo; Esposito, Gennaro; Quadrifoglio, Franco.

In: Journal of Inorganic Biochemistry, Vol. 43, No. 4, 01.01.1991, p. 739-751.

Research output: Contribution to journalArticle

Cauci, Sabina ; Viglino, Paolo ; Esposito, Gennaro ; Quadrifoglio, Franco. / Reaction of the octahedral antitumor complex trans-RuCl2(DMSO)4 with 2′deoxyguanosine. In: Journal of Inorganic Biochemistry. 1991 ; Vol. 43, No. 4. pp. 739-751.
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