Rapid Radial T1 and T2 Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting

Martijn A. Cloos, Jakob Assländer, Batool Abbas, James Fishbaugh, James S. Babb, Guido Gerig, Riccardo Lattanzi

    Research output: Contribution to journalArticle

    Abstract

    Background: Quantitative MRI can detect early changes in cartilage biochemical components, but its routine clinical implementation is challenging. Purpose: To introduce a novel technique to measure T1 and T2 along radial sections of the hip for accurate and reproducible multiparametric quantitative cartilage assessment in a clinically feasible scan time. Study Type: Reproducibility, technical validation. Subjects/Phantom: A seven-compartment phantom and three healthy volunteers. Field Strength/Sequence: A novel MR pulse sequence that simultaneously measures proton density (PD), T1, and T2 at 3 T was developed. Automatic positioning and semiautomatic cartilage segmentation were implemented to improve consistency and simplify workflow. Assessment: Intra- and interscanner variability of our technique was assessed over multiple scans on three different MR scanners. Statistical Tests: For each scan, the median of cartilage T1 and T2 over six radial slices was calculated. Restricted maximum likelihood estimation of variance components was used to estimate intrasubject variances reflecting variation between results from the two scans using the same scanner (intrascanner variance) and variation among results from the three scanners (interscanner variance). Results: The estimation error for T1 and T2 with respect to reference standard measurements was less than 3% on average for the phantom. The average interscanner coefficient of variation was 1.5% (1.2–1.9%) and 0.9% (0.0–3.7%) for T1 and T2, respectively, in the seven compartments of the phantom. Total scan time in vivo was 7:13 minutes to obtain PD, T1, and T2 maps along six radial hip sections at 0.6 × 0.6 × 4.0 mm3 voxel resolution. Interscanner variability for the in vivo study was 1.99% and 5.46% for T1 and T2, respectively. in vivo intrascanner variability was 1.15% for T1 and 3.24% for T2. Data Conclusion: Our method, which includes slice positioning, model-based parameter estimation, and cartilage segmentation, is highly reproducible. It could enable employing quantitative hip cartilage evaluation for longitudinal and multicenter studies. Level of Evidence: 1. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018.

    Original languageEnglish (US)
    JournalJournal of Magnetic Resonance Imaging
    DOIs
    StateAccepted/In press - Jan 1 2018

    Fingerprint

    Articular Cartilage
    Cartilage
    Hip
    Magnetic Resonance Spectroscopy
    Protons
    Workflow
    Multicenter Studies
    Longitudinal Studies
    Healthy Volunteers

    Keywords

    • articular cartilage
    • hip
    • quantitative MRI
    • radial MRI
    • T1 mapping
    • T2 mapping

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

    Cite this

    Cloos, M. A., Assländer, J., Abbas, B., Fishbaugh, J., Babb, J. S., Gerig, G., & Lattanzi, R. (Accepted/In press). Rapid Radial T1 and T2 Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting. Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.26615

    Rapid Radial T1 and T2 Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting. / Cloos, Martijn A.; Assländer, Jakob; Abbas, Batool; Fishbaugh, James; Babb, James S.; Gerig, Guido; Lattanzi, Riccardo.

    In: Journal of Magnetic Resonance Imaging, 01.01.2018.

    Research output: Contribution to journalArticle

    Cloos, Martijn A. ; Assländer, Jakob ; Abbas, Batool ; Fishbaugh, James ; Babb, James S. ; Gerig, Guido ; Lattanzi, Riccardo. / Rapid Radial T1 and T2 Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting. In: Journal of Magnetic Resonance Imaging. 2018.
    @article{c5e1d8691c1f48a5a5c121c23f1e6d53,
    title = "Rapid Radial T1 and T2 Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting",
    abstract = "Background: Quantitative MRI can detect early changes in cartilage biochemical components, but its routine clinical implementation is challenging. Purpose: To introduce a novel technique to measure T1 and T2 along radial sections of the hip for accurate and reproducible multiparametric quantitative cartilage assessment in a clinically feasible scan time. Study Type: Reproducibility, technical validation. Subjects/Phantom: A seven-compartment phantom and three healthy volunteers. Field Strength/Sequence: A novel MR pulse sequence that simultaneously measures proton density (PD), T1, and T2 at 3 T was developed. Automatic positioning and semiautomatic cartilage segmentation were implemented to improve consistency and simplify workflow. Assessment: Intra- and interscanner variability of our technique was assessed over multiple scans on three different MR scanners. Statistical Tests: For each scan, the median of cartilage T1 and T2 over six radial slices was calculated. Restricted maximum likelihood estimation of variance components was used to estimate intrasubject variances reflecting variation between results from the two scans using the same scanner (intrascanner variance) and variation among results from the three scanners (interscanner variance). Results: The estimation error for T1 and T2 with respect to reference standard measurements was less than 3{\%} on average for the phantom. The average interscanner coefficient of variation was 1.5{\%} (1.2–1.9{\%}) and 0.9{\%} (0.0–3.7{\%}) for T1 and T2, respectively, in the seven compartments of the phantom. Total scan time in vivo was 7:13 minutes to obtain PD, T1, and T2 maps along six radial hip sections at 0.6 × 0.6 × 4.0 mm3 voxel resolution. Interscanner variability for the in vivo study was 1.99{\%} and 5.46{\%} for T1 and T2, respectively. in vivo intrascanner variability was 1.15{\%} for T1 and 3.24{\%} for T2. Data Conclusion: Our method, which includes slice positioning, model-based parameter estimation, and cartilage segmentation, is highly reproducible. It could enable employing quantitative hip cartilage evaluation for longitudinal and multicenter studies. Level of Evidence: 1. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018.",
    keywords = "articular cartilage, hip, quantitative MRI, radial MRI, T1 mapping, T2 mapping",
    author = "Cloos, {Martijn A.} and Jakob Assl{\"a}nder and Batool Abbas and James Fishbaugh and Babb, {James S.} and Guido Gerig and Riccardo Lattanzi",
    year = "2018",
    month = "1",
    day = "1",
    doi = "10.1002/jmri.26615",
    language = "English (US)",
    journal = "Journal of Magnetic Resonance Imaging",
    issn = "1053-1807",
    publisher = "John Wiley and Sons Inc.",

    }

    TY - JOUR

    T1 - Rapid Radial T1 and T2 Mapping of the Hip Articular Cartilage With Magnetic Resonance Fingerprinting

    AU - Cloos, Martijn A.

    AU - Assländer, Jakob

    AU - Abbas, Batool

    AU - Fishbaugh, James

    AU - Babb, James S.

    AU - Gerig, Guido

    AU - Lattanzi, Riccardo

    PY - 2018/1/1

    Y1 - 2018/1/1

    N2 - Background: Quantitative MRI can detect early changes in cartilage biochemical components, but its routine clinical implementation is challenging. Purpose: To introduce a novel technique to measure T1 and T2 along radial sections of the hip for accurate and reproducible multiparametric quantitative cartilage assessment in a clinically feasible scan time. Study Type: Reproducibility, technical validation. Subjects/Phantom: A seven-compartment phantom and three healthy volunteers. Field Strength/Sequence: A novel MR pulse sequence that simultaneously measures proton density (PD), T1, and T2 at 3 T was developed. Automatic positioning and semiautomatic cartilage segmentation were implemented to improve consistency and simplify workflow. Assessment: Intra- and interscanner variability of our technique was assessed over multiple scans on three different MR scanners. Statistical Tests: For each scan, the median of cartilage T1 and T2 over six radial slices was calculated. Restricted maximum likelihood estimation of variance components was used to estimate intrasubject variances reflecting variation between results from the two scans using the same scanner (intrascanner variance) and variation among results from the three scanners (interscanner variance). Results: The estimation error for T1 and T2 with respect to reference standard measurements was less than 3% on average for the phantom. The average interscanner coefficient of variation was 1.5% (1.2–1.9%) and 0.9% (0.0–3.7%) for T1 and T2, respectively, in the seven compartments of the phantom. Total scan time in vivo was 7:13 minutes to obtain PD, T1, and T2 maps along six radial hip sections at 0.6 × 0.6 × 4.0 mm3 voxel resolution. Interscanner variability for the in vivo study was 1.99% and 5.46% for T1 and T2, respectively. in vivo intrascanner variability was 1.15% for T1 and 3.24% for T2. Data Conclusion: Our method, which includes slice positioning, model-based parameter estimation, and cartilage segmentation, is highly reproducible. It could enable employing quantitative hip cartilage evaluation for longitudinal and multicenter studies. Level of Evidence: 1. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018.

    AB - Background: Quantitative MRI can detect early changes in cartilage biochemical components, but its routine clinical implementation is challenging. Purpose: To introduce a novel technique to measure T1 and T2 along radial sections of the hip for accurate and reproducible multiparametric quantitative cartilage assessment in a clinically feasible scan time. Study Type: Reproducibility, technical validation. Subjects/Phantom: A seven-compartment phantom and three healthy volunteers. Field Strength/Sequence: A novel MR pulse sequence that simultaneously measures proton density (PD), T1, and T2 at 3 T was developed. Automatic positioning and semiautomatic cartilage segmentation were implemented to improve consistency and simplify workflow. Assessment: Intra- and interscanner variability of our technique was assessed over multiple scans on three different MR scanners. Statistical Tests: For each scan, the median of cartilage T1 and T2 over six radial slices was calculated. Restricted maximum likelihood estimation of variance components was used to estimate intrasubject variances reflecting variation between results from the two scans using the same scanner (intrascanner variance) and variation among results from the three scanners (interscanner variance). Results: The estimation error for T1 and T2 with respect to reference standard measurements was less than 3% on average for the phantom. The average interscanner coefficient of variation was 1.5% (1.2–1.9%) and 0.9% (0.0–3.7%) for T1 and T2, respectively, in the seven compartments of the phantom. Total scan time in vivo was 7:13 minutes to obtain PD, T1, and T2 maps along six radial hip sections at 0.6 × 0.6 × 4.0 mm3 voxel resolution. Interscanner variability for the in vivo study was 1.99% and 5.46% for T1 and T2, respectively. in vivo intrascanner variability was 1.15% for T1 and 3.24% for T2. Data Conclusion: Our method, which includes slice positioning, model-based parameter estimation, and cartilage segmentation, is highly reproducible. It could enable employing quantitative hip cartilage evaluation for longitudinal and multicenter studies. Level of Evidence: 1. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018.

    KW - articular cartilage

    KW - hip

    KW - quantitative MRI

    KW - radial MRI

    KW - T1 mapping

    KW - T2 mapping

    UR - http://www.scopus.com/inward/record.url?scp=85059027805&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85059027805&partnerID=8YFLogxK

    U2 - 10.1002/jmri.26615

    DO - 10.1002/jmri.26615

    M3 - Article

    JO - Journal of Magnetic Resonance Imaging

    JF - Journal of Magnetic Resonance Imaging

    SN - 1053-1807

    ER -