Rapid and highly selective cleavage of ribonucleoside 2',3'-cyclic monophosphates by dinuclear Cu(II) complexes

S. Liu, Z. Luo, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

Two characteristics that never before appeared together are combined in complexes 1 and 2, which show high activity and high selectivity in the hydrolysis of cyclic nucleoside 2',3'-monophosphates as model compounds for RNA. In the case of 1 the regioselectivity is exceptional, and, in the case of 2, the base selectivity.

Original languageEnglish (US)
Pages (from-to)2678-2680
Number of pages3
JournalAngewandte Chemie - International Edition
Volume36
Issue number23
StatePublished - Dec 15 1997

Fingerprint

Ribonucleosides
Regioselectivity
Nucleosides
Hydrolysis
RNA

Keywords

  • Enzyme mimetics
  • Hydrolyses
  • RNA

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Rapid and highly selective cleavage of ribonucleoside 2',3'-cyclic monophosphates by dinuclear Cu(II) complexes. / Liu, S.; Luo, Z.; Hamilton, Andrew.

In: Angewandte Chemie - International Edition, Vol. 36, No. 23, 15.12.1997, p. 2678-2680.

Research output: Contribution to journalArticle

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