Radial glia serve as neuronal progenitors in all regions of the central nervous system

Todd E. Anthony, Corinna Klein, Gordon Fishell, Nathaniel Heintz

Research output: Contribution to journalArticle

Abstract

Radial glial cells function during CNS development as neural progenitors, although their precise contribution to neurogenesis remains controversial. Recent work has argued that regional differences may exist regarding the neurogenic potential of radial glia. Here, we show that the vast majority of neurons in all brain regions derive from radial glia. Cre/loxP fate mapping and clonal analysis demonstrate that radial glia throughout the CNS serve as neuronal progenitors and that radial glia within different regions of the CNS pass through their neurogenic stage of development at distinct time points. Thus, radial glial populations within different CNS regions are not heterogeneous with regard to their potential to generate neurons versus glia.

Original languageEnglish (US)
Pages (from-to)881-890
Number of pages10
JournalNeuron
Volume41
Issue number6
DOIs
StatePublished - Mar 25 2004

Fingerprint

Neuroglia
Central Nervous System
Ependymoglial Cells
Neurons
Neurogenesis
Brain
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Radial glia serve as neuronal progenitors in all regions of the central nervous system. / Anthony, Todd E.; Klein, Corinna; Fishell, Gordon; Heintz, Nathaniel.

In: Neuron, Vol. 41, No. 6, 25.03.2004, p. 881-890.

Research output: Contribution to journalArticle

Anthony, Todd E. ; Klein, Corinna ; Fishell, Gordon ; Heintz, Nathaniel. / Radial glia serve as neuronal progenitors in all regions of the central nervous system. In: Neuron. 2004 ; Vol. 41, No. 6. pp. 881-890.
@article{cf28f62b0b7c48a7a60d9dba5d9c238a,
title = "Radial glia serve as neuronal progenitors in all regions of the central nervous system",
abstract = "Radial glial cells function during CNS development as neural progenitors, although their precise contribution to neurogenesis remains controversial. Recent work has argued that regional differences may exist regarding the neurogenic potential of radial glia. Here, we show that the vast majority of neurons in all brain regions derive from radial glia. Cre/loxP fate mapping and clonal analysis demonstrate that radial glia throughout the CNS serve as neuronal progenitors and that radial glia within different regions of the CNS pass through their neurogenic stage of development at distinct time points. Thus, radial glial populations within different CNS regions are not heterogeneous with regard to their potential to generate neurons versus glia.",
author = "Anthony, {Todd E.} and Corinna Klein and Gordon Fishell and Nathaniel Heintz",
year = "2004",
month = "3",
day = "25",
doi = "10.1016/S0896-6273(04)00140-0",
language = "English (US)",
volume = "41",
pages = "881--890",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Radial glia serve as neuronal progenitors in all regions of the central nervous system

AU - Anthony, Todd E.

AU - Klein, Corinna

AU - Fishell, Gordon

AU - Heintz, Nathaniel

PY - 2004/3/25

Y1 - 2004/3/25

N2 - Radial glial cells function during CNS development as neural progenitors, although their precise contribution to neurogenesis remains controversial. Recent work has argued that regional differences may exist regarding the neurogenic potential of radial glia. Here, we show that the vast majority of neurons in all brain regions derive from radial glia. Cre/loxP fate mapping and clonal analysis demonstrate that radial glia throughout the CNS serve as neuronal progenitors and that radial glia within different regions of the CNS pass through their neurogenic stage of development at distinct time points. Thus, radial glial populations within different CNS regions are not heterogeneous with regard to their potential to generate neurons versus glia.

AB - Radial glial cells function during CNS development as neural progenitors, although their precise contribution to neurogenesis remains controversial. Recent work has argued that regional differences may exist regarding the neurogenic potential of radial glia. Here, we show that the vast majority of neurons in all brain regions derive from radial glia. Cre/loxP fate mapping and clonal analysis demonstrate that radial glia throughout the CNS serve as neuronal progenitors and that radial glia within different regions of the CNS pass through their neurogenic stage of development at distinct time points. Thus, radial glial populations within different CNS regions are not heterogeneous with regard to their potential to generate neurons versus glia.

UR - http://www.scopus.com/inward/record.url?scp=1842527386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842527386&partnerID=8YFLogxK

U2 - 10.1016/S0896-6273(04)00140-0

DO - 10.1016/S0896-6273(04)00140-0

M3 - Article

C2 - 15046721

AN - SCOPUS:1842527386

VL - 41

SP - 881

EP - 890

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 6

ER -