Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder

Matthew J. Hoptman, Jan Volavka, Elisabeth M. Weiss, Pál Czobor, Philip R. Szeszko, Guido Gerig, Miranda Chakos, Joseph Blocher, Leslie L. Citrome, Jean Pierre Lindenmayer, Brian Sheitman, Jeffrey A. Lieberman, Robert M. Bilder

    Research output: Contribution to journalArticle

    Abstract

    The relationship between orbitofrontal cortex (OFC) volumes and functional domains in treatment-resistant patients with schizophrenia or schizoaffective disorder is poorly understood. OFC dysfunction is implicated in several of the behaviors that are abnormal in schizophrenia. However, little is known about the relationship between these behaviors and OFC volumes. Forty-nine patients received magnetic resonance imaging scanning as part of a double-blind treatment study in which psychiatric symptomatology, neuropsychological function, and aggression were measured. OFC volumes were manually traced on anatomical images. Psychiatric symptomatology was measured with the Positive and Negative Syndrome Scale (PANSS). Aggression was measured with the Overt Aggression Scale (OAS) and with the PANSS. Neuropsychological function was assessed using a comprehensive test battery. Larger right OFC volumes were associated with poorer neuropsychological function. Larger left OFC gray matter volumes and larger OFC white matter volumes bilaterally were associated with greater levels of aggression. These findings are discussed in the context of potential iatrogenic effects.

    Original languageEnglish (US)
    Pages (from-to)133-145
    Number of pages13
    JournalPsychiatry Research - Neuroimaging
    Volume140
    Issue number2
    DOIs
    StatePublished - Nov 30 2005

    Fingerprint

    Prefrontal Cortex
    Psychotic Disorders
    Schizophrenia
    Aggression
    Psychiatry
    Double-Blind Method
    Magnetic Resonance Imaging
    Therapeutics

    Keywords

    • Aggression
    • Neuropsychological function
    • Orbitofrontal cortex
    • Schizophrenia

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Radiology Nuclear Medicine and imaging
    • Biological Psychiatry
    • Psychology(all)

    Cite this

    Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder. / Hoptman, Matthew J.; Volavka, Jan; Weiss, Elisabeth M.; Czobor, Pál; Szeszko, Philip R.; Gerig, Guido; Chakos, Miranda; Blocher, Joseph; Citrome, Leslie L.; Lindenmayer, Jean Pierre; Sheitman, Brian; Lieberman, Jeffrey A.; Bilder, Robert M.

    In: Psychiatry Research - Neuroimaging, Vol. 140, No. 2, 30.11.2005, p. 133-145.

    Research output: Contribution to journalArticle

    Hoptman, MJ, Volavka, J, Weiss, EM, Czobor, P, Szeszko, PR, Gerig, G, Chakos, M, Blocher, J, Citrome, LL, Lindenmayer, JP, Sheitman, B, Lieberman, JA & Bilder, RM 2005, 'Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder', Psychiatry Research - Neuroimaging, vol. 140, no. 2, pp. 133-145. https://doi.org/10.1016/j.pscychresns.2005.07.004
    Hoptman, Matthew J. ; Volavka, Jan ; Weiss, Elisabeth M. ; Czobor, Pál ; Szeszko, Philip R. ; Gerig, Guido ; Chakos, Miranda ; Blocher, Joseph ; Citrome, Leslie L. ; Lindenmayer, Jean Pierre ; Sheitman, Brian ; Lieberman, Jeffrey A. ; Bilder, Robert M. / Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder. In: Psychiatry Research - Neuroimaging. 2005 ; Vol. 140, No. 2. pp. 133-145.
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