Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil

Dan Sanes, W. A. Geary, G. F. Wooten, E. W. Rubel

Research output: Contribution to journalArticle

Abstract

The concentration and relative distribution of glycine receptors were determined for gerbil brain stem auditory nuclei using 3H-strychnine and quantitative autoradiographic techniques. Significant binding was observed in the anteroventral cochlear nucleus, the dorsal cochlear nucleus, the lateral superior olivary nucleus, and the inferior colliculus. A non-uniform distribution of binding was seen in 3 of these nuclei, such that the greatest concentration of glycine receptors was located in the high-frequency regions. An analysis of neuron soma density suggested that the amount of post-synaptic membrane could partially explain the distribution of receptor.

Original languageEnglish (US)
Pages (from-to)3793-3802
Number of pages10
JournalJournal of Neuroscience
Volume7
Issue number11
StatePublished - 1987

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Glycine Receptors
Cochlear Nucleus
Gerbillinae
Brain Stem
Lateral Thalamic Nuclei
Inferior Colliculi
Synaptic Membranes
Strychnine
Carisoprodol
Neurons
Superior Olivary Complex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil. / Sanes, Dan; Geary, W. A.; Wooten, G. F.; Rubel, E. W.

In: Journal of Neuroscience, Vol. 7, No. 11, 1987, p. 3793-3802.

Research output: Contribution to journalArticle

Sanes, Dan ; Geary, W. A. ; Wooten, G. F. ; Rubel, E. W. / Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil. In: Journal of Neuroscience. 1987 ; Vol. 7, No. 11. pp. 3793-3802.
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