Quantitative analysis of retinal ganglion cell classifications

S. Hochstein, Robert Shapley

Research output: Contribution to journalArticle

Abstract

The classification of cat retinal ganglion cells as X or Y on the basis of linearity or nonlinearity of spatial summation has been confirmed and extended. Recordings were taken from optic tract fibres of anesthetized, paralysed cats. When an alternating phase sine wave grating was used as a stimulus, X cells had null positions and Y cells responded at all positions of the grating. These results did not depend on the temporal wave form or the temporal frequency of pattern alternation over a wide range. At high spatial frequencies for the particular cell, a Y cell gave a big 'on-off' response, or frequency doubling, at all positions of the grating, while an X cell did not. The use of contrast sensitivity versus spatial phase also served to differentiate the two cell types. With an alternating sine grating stimulus X cells had a sinusoidal dependence on spatial phase, while each Y cell's sensitivity depended in a complicated manner on spatial phase. Sensitivity versus spatial phase for different Fourier components of the neural response also separated the two classes of cells. Significant second harmonic distortion was present in Y cells. The second harmonic component was spatial phase insensitive, and became dominant at high spatial frequencies. The maximum of the 2nd/1st harmonic ratio was taken as an index of nonlinearity. X cells always had a nonlinearity index less than 1 while in Y cells this index always exceeded 1. Response to spots, diffuse light and drifting gratings were compared to the nonlinearity index as a basis for classifying cells. The nonlinearity index was most reliable because it was least dependent on retinal eccentricity.

Original languageEnglish (US)
Pages (from-to)237-264
Number of pages28
JournalJournal of Physiology
Volume262
Issue number2
StatePublished - 1976

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Retinal Ganglion Cells
Cats
Null Lymphocytes
Contrast Sensitivity

ASJC Scopus subject areas

  • Physiology

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Quantitative analysis of retinal ganglion cell classifications. / Hochstein, S.; Shapley, Robert.

In: Journal of Physiology, Vol. 262, No. 2, 1976, p. 237-264.

Research output: Contribution to journalArticle

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