Quantifying gene expression

the importance of being subtle

Gustavo Monteiro Silva, Christine Vogel

Research output: Contribution to journalArticle

Abstract

Gene expression is regulated at both the mRNA and protein level through on-off switches and fine-tuned control. In their recent study, Edfors et al (2016) use highly accurate, targeted proteomics methods and examine to what extent the amount of protein produced per mRNA transcript varies across different tissues. They find that the bulk part of protein concentrations is set at a per-gene level: This relationship, the protein/mRNA ratio, is constant across cell types and tissues, but varies by several orders of magnitude across genes.

Original languageEnglish (US)
Article number885
JournalMolecular Systems Biology
Volume12
Issue number10
DOIs
StatePublished - Oct 1 2016

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Gene expression
Gene Expression
Messenger RNA
Proteins
Protein
gene expression
proteins
Genes
Vary
Tissue
Gene
Proteomics
proteomics
Switch
genes
Switches
Cell
cells
tissues
methodology

ASJC Scopus subject areas

  • Medicine(all)
  • Information Systems
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics
  • Applied Mathematics

Cite this

Quantifying gene expression : the importance of being subtle. / Silva, Gustavo Monteiro; Vogel, Christine.

In: Molecular Systems Biology, Vol. 12, No. 10, 885, 01.10.2016.

Research output: Contribution to journalArticle

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