Putting fear in its place

Remapping of hippocampal place cells during fear conditioning

Marta A P Moita, Svetlana Rosis, Yu Zhou, Joseph Ledoux, Hugh T. Blair

Research output: Contribution to journalArticle

Abstract

We recorded hippocampal place cells in two spatial environments: a training environment in which rats underwent fear conditioning and a neutral control environment. Fear conditioning caused many place cells to alter (or remap) their preferred firing locations in the training environment, whereas most cells remained stable in the control environment. This finding indicates that aversive reinforcement can induce place cell remapping even when the environment itself remains unchanged. Furthermore, contextual fear conditioning caused significantly more remapping of place cells than auditory fear conditioning, suggesting that place cell remapping was related to the rat's learned fear of the environment. These results suggest that one possible function of place cell remapping may be to generate new spatial representations of a single environment, which could help the animal to discriminate among different motivational contexts within that environment.

Original languageEnglish (US)
Pages (from-to)7015-7023
Number of pages9
JournalJournal of Neuroscience
Volume24
Issue number31
DOIs
StatePublished - Aug 4 2004

Fingerprint

Fear
Conditioning (Psychology)
Place Cells

Keywords

  • Activity
  • Aversion
  • CA1
  • Conditioned (conditioning)
  • Extracellular
  • Hippocampus
  • Learning

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Putting fear in its place : Remapping of hippocampal place cells during fear conditioning. / Moita, Marta A P; Rosis, Svetlana; Zhou, Yu; Ledoux, Joseph; Blair, Hugh T.

In: Journal of Neuroscience, Vol. 24, No. 31, 04.08.2004, p. 7015-7023.

Research output: Contribution to journalArticle

Moita, Marta A P ; Rosis, Svetlana ; Zhou, Yu ; Ledoux, Joseph ; Blair, Hugh T. / Putting fear in its place : Remapping of hippocampal place cells during fear conditioning. In: Journal of Neuroscience. 2004 ; Vol. 24, No. 31. pp. 7015-7023.
@article{0ddf47e588234966b030530d8ffa8001,
title = "Putting fear in its place: Remapping of hippocampal place cells during fear conditioning",
abstract = "We recorded hippocampal place cells in two spatial environments: a training environment in which rats underwent fear conditioning and a neutral control environment. Fear conditioning caused many place cells to alter (or remap) their preferred firing locations in the training environment, whereas most cells remained stable in the control environment. This finding indicates that aversive reinforcement can induce place cell remapping even when the environment itself remains unchanged. Furthermore, contextual fear conditioning caused significantly more remapping of place cells than auditory fear conditioning, suggesting that place cell remapping was related to the rat's learned fear of the environment. These results suggest that one possible function of place cell remapping may be to generate new spatial representations of a single environment, which could help the animal to discriminate among different motivational contexts within that environment.",
keywords = "Activity, Aversion, CA1, Conditioned (conditioning), Extracellular, Hippocampus, Learning",
author = "Moita, {Marta A P} and Svetlana Rosis and Yu Zhou and Joseph Ledoux and Blair, {Hugh T.}",
year = "2004",
month = "8",
day = "4",
doi = "10.1523/JNEUROSCI.5492-03.2004",
language = "English (US)",
volume = "24",
pages = "7015--7023",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "31",

}

TY - JOUR

T1 - Putting fear in its place

T2 - Remapping of hippocampal place cells during fear conditioning

AU - Moita, Marta A P

AU - Rosis, Svetlana

AU - Zhou, Yu

AU - Ledoux, Joseph

AU - Blair, Hugh T.

PY - 2004/8/4

Y1 - 2004/8/4

N2 - We recorded hippocampal place cells in two spatial environments: a training environment in which rats underwent fear conditioning and a neutral control environment. Fear conditioning caused many place cells to alter (or remap) their preferred firing locations in the training environment, whereas most cells remained stable in the control environment. This finding indicates that aversive reinforcement can induce place cell remapping even when the environment itself remains unchanged. Furthermore, contextual fear conditioning caused significantly more remapping of place cells than auditory fear conditioning, suggesting that place cell remapping was related to the rat's learned fear of the environment. These results suggest that one possible function of place cell remapping may be to generate new spatial representations of a single environment, which could help the animal to discriminate among different motivational contexts within that environment.

AB - We recorded hippocampal place cells in two spatial environments: a training environment in which rats underwent fear conditioning and a neutral control environment. Fear conditioning caused many place cells to alter (or remap) their preferred firing locations in the training environment, whereas most cells remained stable in the control environment. This finding indicates that aversive reinforcement can induce place cell remapping even when the environment itself remains unchanged. Furthermore, contextual fear conditioning caused significantly more remapping of place cells than auditory fear conditioning, suggesting that place cell remapping was related to the rat's learned fear of the environment. These results suggest that one possible function of place cell remapping may be to generate new spatial representations of a single environment, which could help the animal to discriminate among different motivational contexts within that environment.

KW - Activity

KW - Aversion

KW - CA1

KW - Conditioned (conditioning)

KW - Extracellular

KW - Hippocampus

KW - Learning

UR - http://www.scopus.com/inward/record.url?scp=3843125474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3843125474&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.5492-03.2004

DO - 10.1523/JNEUROSCI.5492-03.2004

M3 - Article

VL - 24

SP - 7015

EP - 7023

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 31

ER -