Pulp revascularization of replanted immature dog teeth after treatment with minocycline and doxycycline assessed by laser Doppler flowmetry, radiography, and histology

Alessandra Luisa De Souza Ritter, André Vicente Ritter, Valerie Murrah, Asgeir Sigurdsson, Martin Trope

Research output: Contribution to journalArticle

Abstract

This study investigated the effect of topical antibiotic treatment on pulp revascularization in replanted teeth. Thirty-four immature teeth were selected from three young dogs. Baseline radiographs and laser Doppler flowmetry (LDF) readings were obtained. Specimens were randomly divided into four groups: Thirty-eight teeth were extracted, kept dry for 5 min, and either (Group 1) covered with minocycline mixture (G1, n = 11), (Group 2) soaked in doxycycline (G2, n = 11), or (Group 3) soaked in saline (G3-negative control, n = 6), and replanted. Teeth in Group 4 were not extracted (positive control, n = 6). Postoperative radiographs and LDF readings were obtained for 2 months after replantation. After sacrifice, the jaws were collected and processed for light microscopy. Pre- and postreplantation LDF readings and radiographs, and histologic findings were analyzed to assess revascularization. Pulp revascularization occurred in 91% (G1), 73% (G2), and 33% (G3) of the specimens. In conclusion, minocycline facilitates pulp revascularization in replanted immature teeth after replantation.

Original languageEnglish (US)
Pages (from-to)75-84
Number of pages10
JournalDental Traumatology
Volume20
Issue number2
StatePublished - Apr 2004

Fingerprint

Laser-Doppler Flowmetry
Minocycline
Doxycycline
Radiography
Histology
Tooth
Dogs
Reading
Tooth Replantation
Replantation
Therapeutics
Jaw
Microscopy
Anti-Bacterial Agents
Light

Keywords

  • Dental trauma
  • Doxycycline
  • Laser Doppler flowmetry
  • Minocycline
  • Replantation
  • Revascularization

ASJC Scopus subject areas

  • Surgery
  • Dentistry(all)

Cite this

Pulp revascularization of replanted immature dog teeth after treatment with minocycline and doxycycline assessed by laser Doppler flowmetry, radiography, and histology. / Ritter, Alessandra Luisa De Souza; Ritter, André Vicente; Murrah, Valerie; Sigurdsson, Asgeir; Trope, Martin.

In: Dental Traumatology, Vol. 20, No. 2, 04.2004, p. 75-84.

Research output: Contribution to journalArticle

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AU - Trope, Martin

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N2 - This study investigated the effect of topical antibiotic treatment on pulp revascularization in replanted teeth. Thirty-four immature teeth were selected from three young dogs. Baseline radiographs and laser Doppler flowmetry (LDF) readings were obtained. Specimens were randomly divided into four groups: Thirty-eight teeth were extracted, kept dry for 5 min, and either (Group 1) covered with minocycline mixture (G1, n = 11), (Group 2) soaked in doxycycline (G2, n = 11), or (Group 3) soaked in saline (G3-negative control, n = 6), and replanted. Teeth in Group 4 were not extracted (positive control, n = 6). Postoperative radiographs and LDF readings were obtained for 2 months after replantation. After sacrifice, the jaws were collected and processed for light microscopy. Pre- and postreplantation LDF readings and radiographs, and histologic findings were analyzed to assess revascularization. Pulp revascularization occurred in 91% (G1), 73% (G2), and 33% (G3) of the specimens. In conclusion, minocycline facilitates pulp revascularization in replanted immature teeth after replantation.

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