Psychosocial and immunological factors in neurasthenia

Yu Ping Cao, Ya Lin Zhang, Doris F. Chang, Guo Qiang Wang, Xiang Hui Zhang

    Research output: Contribution to journalArticle

    Abstract

    Background: Neurasthenia is a disorder whose pathogenesis is still unknown. Objective: The authors sought to examine the relationships between neurasthenia and possible psychosocial and immunological correlates. Method: A sample of 30 Chinese neurasthenic patients was compared with a matched sample of 30 control subjects for 1) the level of serum Epstein-Barr virus (EBV) gamma G immunoglobulin (IgG) and gamma M immunoglobulin (IgM); 2) scores on the Eysenck Personality Questionnaire (EPQ); 3) the Symptom Checklist-90; and 4) the Life Event Scale (LES); 27 of the 30 neurasthenia patients were treated with medication and psychotherapy for a 4-month period, with measures taken pre- and posttreatment. Results: As compared with the control group, neurasthenic patients exhibited higher EPQ scores for neuroticism, higher levels of introversion, and a higher number of negative life events. Within the neurasthenia sample, scores for neuroticism and the SCL-90 Global Severity Index were significantly lower at follow-up than at baseline. Conclusion: As compared with control subjects, neurasthenia patients were characterized by greater neuroticism and introversion, and they reported a higher rate of negative life events. Moreover, the positive rate of EBV in neurasthenic patients was higher, which may be associated with higher EBV activation under states of stress.

    Original languageEnglish (US)
    Pages (from-to)24-29
    Number of pages6
    JournalPsychosomatics
    Volume50
    Issue number1
    DOIs
    StatePublished - Jan 1 2009

    Fingerprint

    Neurasthenia
    Immunologic Factors
    Psychology
    Human Herpesvirus 4
    Personality
    Immunoglobulin G
    Virus Activation
    Checklist
    Psychotherapy
    Immunoglobulin M
    Control Groups
    Serum
    Neuroticism
    Virus
    Life Events

    ASJC Scopus subject areas

    • Arts and Humanities (miscellaneous)
    • Applied Psychology
    • Psychiatry and Mental health

    Cite this

    Cao, Y. P., Zhang, Y. L., Chang, D. F., Wang, G. Q., & Zhang, X. H. (2009). Psychosocial and immunological factors in neurasthenia. Psychosomatics, 50(1), 24-29. https://doi.org/10.1176/appi.psy.50.1.24

    Psychosocial and immunological factors in neurasthenia. / Cao, Yu Ping; Zhang, Ya Lin; Chang, Doris F.; Wang, Guo Qiang; Zhang, Xiang Hui.

    In: Psychosomatics, Vol. 50, No. 1, 01.01.2009, p. 24-29.

    Research output: Contribution to journalArticle

    Cao, YP, Zhang, YL, Chang, DF, Wang, GQ & Zhang, XH 2009, 'Psychosocial and immunological factors in neurasthenia', Psychosomatics, vol. 50, no. 1, pp. 24-29. https://doi.org/10.1176/appi.psy.50.1.24
    Cao YP, Zhang YL, Chang DF, Wang GQ, Zhang XH. Psychosocial and immunological factors in neurasthenia. Psychosomatics. 2009 Jan 1;50(1):24-29. https://doi.org/10.1176/appi.psy.50.1.24
    Cao, Yu Ping ; Zhang, Ya Lin ; Chang, Doris F. ; Wang, Guo Qiang ; Zhang, Xiang Hui. / Psychosocial and immunological factors in neurasthenia. In: Psychosomatics. 2009 ; Vol. 50, No. 1. pp. 24-29.
    @article{11d06323e44440b59563790e08935d3d,
    title = "Psychosocial and immunological factors in neurasthenia",
    abstract = "Background: Neurasthenia is a disorder whose pathogenesis is still unknown. Objective: The authors sought to examine the relationships between neurasthenia and possible psychosocial and immunological correlates. Method: A sample of 30 Chinese neurasthenic patients was compared with a matched sample of 30 control subjects for 1) the level of serum Epstein-Barr virus (EBV) gamma G immunoglobulin (IgG) and gamma M immunoglobulin (IgM); 2) scores on the Eysenck Personality Questionnaire (EPQ); 3) the Symptom Checklist-90; and 4) the Life Event Scale (LES); 27 of the 30 neurasthenia patients were treated with medication and psychotherapy for a 4-month period, with measures taken pre- and posttreatment. Results: As compared with the control group, neurasthenic patients exhibited higher EPQ scores for neuroticism, higher levels of introversion, and a higher number of negative life events. Within the neurasthenia sample, scores for neuroticism and the SCL-90 Global Severity Index were significantly lower at follow-up than at baseline. Conclusion: As compared with control subjects, neurasthenia patients were characterized by greater neuroticism and introversion, and they reported a higher rate of negative life events. Moreover, the positive rate of EBV in neurasthenic patients was higher, which may be associated with higher EBV activation under states of stress.",
    author = "Cao, {Yu Ping} and Zhang, {Ya Lin} and Chang, {Doris F.} and Wang, {Guo Qiang} and Zhang, {Xiang Hui}",
    year = "2009",
    month = "1",
    day = "1",
    doi = "10.1176/appi.psy.50.1.24",
    language = "English (US)",
    volume = "50",
    pages = "24--29",
    journal = "Psychosomatics",
    issn = "0033-3182",
    publisher = "American Psychiatric Publishing Inc.",
    number = "1",

    }

    TY - JOUR

    T1 - Psychosocial and immunological factors in neurasthenia

    AU - Cao, Yu Ping

    AU - Zhang, Ya Lin

    AU - Chang, Doris F.

    AU - Wang, Guo Qiang

    AU - Zhang, Xiang Hui

    PY - 2009/1/1

    Y1 - 2009/1/1

    N2 - Background: Neurasthenia is a disorder whose pathogenesis is still unknown. Objective: The authors sought to examine the relationships between neurasthenia and possible psychosocial and immunological correlates. Method: A sample of 30 Chinese neurasthenic patients was compared with a matched sample of 30 control subjects for 1) the level of serum Epstein-Barr virus (EBV) gamma G immunoglobulin (IgG) and gamma M immunoglobulin (IgM); 2) scores on the Eysenck Personality Questionnaire (EPQ); 3) the Symptom Checklist-90; and 4) the Life Event Scale (LES); 27 of the 30 neurasthenia patients were treated with medication and psychotherapy for a 4-month period, with measures taken pre- and posttreatment. Results: As compared with the control group, neurasthenic patients exhibited higher EPQ scores for neuroticism, higher levels of introversion, and a higher number of negative life events. Within the neurasthenia sample, scores for neuroticism and the SCL-90 Global Severity Index were significantly lower at follow-up than at baseline. Conclusion: As compared with control subjects, neurasthenia patients were characterized by greater neuroticism and introversion, and they reported a higher rate of negative life events. Moreover, the positive rate of EBV in neurasthenic patients was higher, which may be associated with higher EBV activation under states of stress.

    AB - Background: Neurasthenia is a disorder whose pathogenesis is still unknown. Objective: The authors sought to examine the relationships between neurasthenia and possible psychosocial and immunological correlates. Method: A sample of 30 Chinese neurasthenic patients was compared with a matched sample of 30 control subjects for 1) the level of serum Epstein-Barr virus (EBV) gamma G immunoglobulin (IgG) and gamma M immunoglobulin (IgM); 2) scores on the Eysenck Personality Questionnaire (EPQ); 3) the Symptom Checklist-90; and 4) the Life Event Scale (LES); 27 of the 30 neurasthenia patients were treated with medication and psychotherapy for a 4-month period, with measures taken pre- and posttreatment. Results: As compared with the control group, neurasthenic patients exhibited higher EPQ scores for neuroticism, higher levels of introversion, and a higher number of negative life events. Within the neurasthenia sample, scores for neuroticism and the SCL-90 Global Severity Index were significantly lower at follow-up than at baseline. Conclusion: As compared with control subjects, neurasthenia patients were characterized by greater neuroticism and introversion, and they reported a higher rate of negative life events. Moreover, the positive rate of EBV in neurasthenic patients was higher, which may be associated with higher EBV activation under states of stress.

    UR - http://www.scopus.com/inward/record.url?scp=61849174806&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=61849174806&partnerID=8YFLogxK

    U2 - 10.1176/appi.psy.50.1.24

    DO - 10.1176/appi.psy.50.1.24

    M3 - Article

    C2 - 19213969

    AN - SCOPUS:61849174806

    VL - 50

    SP - 24

    EP - 29

    JO - Psychosomatics

    JF - Psychosomatics

    SN - 0033-3182

    IS - 1

    ER -