Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold

Rishi K. Jain, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

(matrix presented) Receptors based on a tetraphenylporphyrin scaffold bearing different charged and hydrophobic groups have been synthesized. The interactions of these with horse heart cytochrome c were studied by fluorescence spectroscopy. Receptor 4 was identified to be the strongest synthetic receptor (Kd = 20 nM) for cytochrome c. The differences in affinity among the receptors reflected a dependence on the number of anionic and hydrophobic groups.

Original languageEnglish (US)
Pages (from-to)1721-1723
Number of pages3
JournalOrganic Letters
Volume2
Issue number12
DOIs
StatePublished - Jun 15 2000

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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