Protein recognition using synthetic surface-targeted agents

Rishi Jain, Justin T. Ernst, Olaf Kutzki, Soon Park Hyung, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

The design of synthetic agents to disrupt protein-protein interactions has received relatively little attention in recent years. In this review we describe strategies for targeting different types of protein surfaces using mimetics of protein secondary or tertiary structure. In this way strong and selective binding to a protein surface has be achieved and disruption of clinically important protein-protein interactions has been demonstrated in models of human disease.

Original languageEnglish (US)
Pages (from-to)89-100
Number of pages12
JournalMolecular Diversity
Volume8
Issue number2
DOIs
StatePublished - 2004

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proteins
Proteins
Membrane Proteins
Secondary Protein Structure
Protein Transport
Tertiary Protein Structure
interactions

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry

Cite this

Protein recognition using synthetic surface-targeted agents. / Jain, Rishi; Ernst, Justin T.; Kutzki, Olaf; Hyung, Soon Park; Hamilton, Andrew.

In: Molecular Diversity, Vol. 8, No. 2, 2004, p. 89-100.

Research output: Contribution to journalArticle

Jain, Rishi ; Ernst, Justin T. ; Kutzki, Olaf ; Hyung, Soon Park ; Hamilton, Andrew. / Protein recognition using synthetic surface-targeted agents. In: Molecular Diversity. 2004 ; Vol. 8, No. 2. pp. 89-100.
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