Protein recognition by an ensemble of fluorescent DNA G-quadruplexes

David Margulies, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

Sniffing out proteins: Fluorescent DNA G-quadruplexes have been used for building versatile signaling receptors for proteins in a single solution. Introducing a protein sample to the ensemble results in a unique emission signature for unambiguous identification (see scheme, R=fluorophore). The self-assembled, pattern-based protein detection systems are easily fabricated, have the potential for high-throughput operations, and have the ability to handle small protein samples.

Original languageEnglish (US)
Pages (from-to)1771-1774
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number10
DOIs
StatePublished - Feb 23 2009

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DNA
Proteins
Fluorophores
Throughput

Keywords

  • DNA
  • Fluorescence
  • Proteins
  • Self-assembly
  • Supramolecular chemistry

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Protein recognition by an ensemble of fluorescent DNA G-quadruplexes. / Margulies, David; Hamilton, Andrew.

In: Angewandte Chemie - International Edition, Vol. 48, No. 10, 23.02.2009, p. 1771-1774.

Research output: Contribution to journalArticle

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