Protein-protein interaction inhibitors

Small molecules from screening techniques

Steven Fletcher, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

Protein-protein interactions play crucial roles in a number of biological processes, and, as such, their disruption is becoming an area of intense research. Despite the many challenges associated with the development of protein-protein interaction inhibitors, such as the large and relatively featureless interfacial areas involved, there has been considerable success in recent years. Importantly, through the existence of protein "hot spots", some of this success takes the form of small molecule inhibitors that have been identified from a variety of screening techniques.

Original languageEnglish (US)
Pages (from-to)922-927
Number of pages6
JournalCurrent Topics in Medicinal Chemistry
Volume7
Issue number10
DOIs
StatePublished - May 2007

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Screening
Molecules
Proteins
Biological Phenomena
Research

Keywords

  • Herpes simplex virus
  • Interleukin-2
  • T cell factor
  • The p53-MDM2 interaction
  • Thyroid hormone receptor

ASJC Scopus subject areas

  • Medicine(all)
  • Chemistry(all)

Cite this

Protein-protein interaction inhibitors : Small molecules from screening techniques. / Fletcher, Steven; Hamilton, Andrew.

In: Current Topics in Medicinal Chemistry, Vol. 7, No. 10, 05.2007, p. 922-927.

Research output: Contribution to journalArticle

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