Protein flexibility and the correlation ratchet

Timothy C. Elston, Dwight You, Charles Peskin

Research output: Contribution to journalArticle

Abstract

Biomolecular motors are tiny engines that transport material at the microscopic level within biological cells. Since biomolecular motors typically transport cargo that are much larger than themselves, one would expect the speed of such a motor to be severely limited by the small diffusion coefficient of its enormous cargo. It has been suggested by Berg and Kahn [Mobility and Recognition in Cell Biology, H. Sund and C. Veeger, eds., De Gruyter, Berlin, 1983] and Meister, Caplan, and Berg [Biophys. J., 55 (1989), pp. 905-914] that this limitation can be overcome if the tether that connects the motor to its cargo is sufficiently elastic. In a recent article the effects of the elastic properties of the tether on the speed of the motor were investigated when the driving mechanism was a Brownian ratchet [SIAM J. Appl. Math., 60 (2000), pp. 842-867]. Here we extend that work to include the correlation ratchet [C. Peskin, G. Ermentrout, and G. Oster, in Mechanics and Cellular Engineering, V. Mow et al., eds., Springer, New York, 1994; Phys. Rev. Lett., 72 (1994), pp. 2652-2655; Phys. Rev. Lett., 72 (1994), pp. 1766-1769]. In contrast to the Brownian ratchet, it is shown that in the limit of a large motor diffusion coefficient the average velocity increases monotonically as the stiffness of the tether is increased. However, Monte-Carlo simulations reveal that for any finite diffusion coefficient of the motor there is an optimal stiffness at which the motor travels fastest.

Original languageEnglish (US)
Pages (from-to)776-791
Number of pages16
JournalSIAM Journal on Applied Mathematics
Volume61
Issue number3
StatePublished - 2000

Fingerprint

Ratchet
Flexibility
Proteins
Protein
Brownian Ratchet
Diffusion Coefficient
Stiffness
Cytology
Cell
Elastic Properties
Biology
Mechanics
Engine
Monte Carlo Simulation
Engines
Engineering

Keywords

  • Biomolecular motors
  • Correlation ratchet
  • Diffusion equation
  • Protein flexibility
  • Stochastic processes

ASJC Scopus subject areas

  • Mathematics(all)
  • Applied Mathematics

Cite this

Elston, T. C., You, D., & Peskin, C. (2000). Protein flexibility and the correlation ratchet. SIAM Journal on Applied Mathematics, 61(3), 776-791.

Protein flexibility and the correlation ratchet. / Elston, Timothy C.; You, Dwight; Peskin, Charles.

In: SIAM Journal on Applied Mathematics, Vol. 61, No. 3, 2000, p. 776-791.

Research output: Contribution to journalArticle

Elston, TC, You, D & Peskin, C 2000, 'Protein flexibility and the correlation ratchet', SIAM Journal on Applied Mathematics, vol. 61, no. 3, pp. 776-791.
Elston, Timothy C. ; You, Dwight ; Peskin, Charles. / Protein flexibility and the correlation ratchet. In: SIAM Journal on Applied Mathematics. 2000 ; Vol. 61, No. 3. pp. 776-791.
@article{c700cb5973024aae82e9152f98767a44,
title = "Protein flexibility and the correlation ratchet",
abstract = "Biomolecular motors are tiny engines that transport material at the microscopic level within biological cells. Since biomolecular motors typically transport cargo that are much larger than themselves, one would expect the speed of such a motor to be severely limited by the small diffusion coefficient of its enormous cargo. It has been suggested by Berg and Kahn [Mobility and Recognition in Cell Biology, H. Sund and C. Veeger, eds., De Gruyter, Berlin, 1983] and Meister, Caplan, and Berg [Biophys. J., 55 (1989), pp. 905-914] that this limitation can be overcome if the tether that connects the motor to its cargo is sufficiently elastic. In a recent article the effects of the elastic properties of the tether on the speed of the motor were investigated when the driving mechanism was a Brownian ratchet [SIAM J. Appl. Math., 60 (2000), pp. 842-867]. Here we extend that work to include the correlation ratchet [C. Peskin, G. Ermentrout, and G. Oster, in Mechanics and Cellular Engineering, V. Mow et al., eds., Springer, New York, 1994; Phys. Rev. Lett., 72 (1994), pp. 2652-2655; Phys. Rev. Lett., 72 (1994), pp. 1766-1769]. In contrast to the Brownian ratchet, it is shown that in the limit of a large motor diffusion coefficient the average velocity increases monotonically as the stiffness of the tether is increased. However, Monte-Carlo simulations reveal that for any finite diffusion coefficient of the motor there is an optimal stiffness at which the motor travels fastest.",
keywords = "Biomolecular motors, Correlation ratchet, Diffusion equation, Protein flexibility, Stochastic processes",
author = "Elston, {Timothy C.} and Dwight You and Charles Peskin",
year = "2000",
language = "English (US)",
volume = "61",
pages = "776--791",
journal = "SIAM Journal on Applied Mathematics",
issn = "0036-1399",
publisher = "Society for Industrial and Applied Mathematics Publications",
number = "3",

}

TY - JOUR

T1 - Protein flexibility and the correlation ratchet

AU - Elston, Timothy C.

AU - You, Dwight

AU - Peskin, Charles

PY - 2000

Y1 - 2000

N2 - Biomolecular motors are tiny engines that transport material at the microscopic level within biological cells. Since biomolecular motors typically transport cargo that are much larger than themselves, one would expect the speed of such a motor to be severely limited by the small diffusion coefficient of its enormous cargo. It has been suggested by Berg and Kahn [Mobility and Recognition in Cell Biology, H. Sund and C. Veeger, eds., De Gruyter, Berlin, 1983] and Meister, Caplan, and Berg [Biophys. J., 55 (1989), pp. 905-914] that this limitation can be overcome if the tether that connects the motor to its cargo is sufficiently elastic. In a recent article the effects of the elastic properties of the tether on the speed of the motor were investigated when the driving mechanism was a Brownian ratchet [SIAM J. Appl. Math., 60 (2000), pp. 842-867]. Here we extend that work to include the correlation ratchet [C. Peskin, G. Ermentrout, and G. Oster, in Mechanics and Cellular Engineering, V. Mow et al., eds., Springer, New York, 1994; Phys. Rev. Lett., 72 (1994), pp. 2652-2655; Phys. Rev. Lett., 72 (1994), pp. 1766-1769]. In contrast to the Brownian ratchet, it is shown that in the limit of a large motor diffusion coefficient the average velocity increases monotonically as the stiffness of the tether is increased. However, Monte-Carlo simulations reveal that for any finite diffusion coefficient of the motor there is an optimal stiffness at which the motor travels fastest.

AB - Biomolecular motors are tiny engines that transport material at the microscopic level within biological cells. Since biomolecular motors typically transport cargo that are much larger than themselves, one would expect the speed of such a motor to be severely limited by the small diffusion coefficient of its enormous cargo. It has been suggested by Berg and Kahn [Mobility and Recognition in Cell Biology, H. Sund and C. Veeger, eds., De Gruyter, Berlin, 1983] and Meister, Caplan, and Berg [Biophys. J., 55 (1989), pp. 905-914] that this limitation can be overcome if the tether that connects the motor to its cargo is sufficiently elastic. In a recent article the effects of the elastic properties of the tether on the speed of the motor were investigated when the driving mechanism was a Brownian ratchet [SIAM J. Appl. Math., 60 (2000), pp. 842-867]. Here we extend that work to include the correlation ratchet [C. Peskin, G. Ermentrout, and G. Oster, in Mechanics and Cellular Engineering, V. Mow et al., eds., Springer, New York, 1994; Phys. Rev. Lett., 72 (1994), pp. 2652-2655; Phys. Rev. Lett., 72 (1994), pp. 1766-1769]. In contrast to the Brownian ratchet, it is shown that in the limit of a large motor diffusion coefficient the average velocity increases monotonically as the stiffness of the tether is increased. However, Monte-Carlo simulations reveal that for any finite diffusion coefficient of the motor there is an optimal stiffness at which the motor travels fastest.

KW - Biomolecular motors

KW - Correlation ratchet

KW - Diffusion equation

KW - Protein flexibility

KW - Stochastic processes

UR - http://www.scopus.com/inward/record.url?scp=0034912149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034912149&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0034912149

VL - 61

SP - 776

EP - 791

JO - SIAM Journal on Applied Mathematics

JF - SIAM Journal on Applied Mathematics

SN - 0036-1399

IS - 3

ER -