Protein based therapeutic delivery agents: Contemporary developments and challenges

Liming Yin, Carlo Yuvienco, Jin Kim Montclare

Research output: Contribution to journalReview article

Abstract

As unique biopolymers, proteins can be employed for therapeutic delivery. They bear important features such as bioavailability, biocompatibility, and biodegradability with low toxicity serving as a platform for delivery of various small molecule therapeutics, gene therapies, protein biologics and cells. Depending on size and characteristic of the therapeutic, a variety of natural and engineered proteins or peptides have been developed. This, coupled to recent advances in synthetic and chemical biology, has led to the creation of tailor-made protein materials for delivery. This review highlights strategies employing proteins to facilitate the delivery of therapeutic matter, addressing the challenges for small molecule, gene, protein and cell transport.

Original languageEnglish (US)
Pages (from-to)91-116
Number of pages26
JournalBiomaterials
Volume134
DOIs
StatePublished - Jul 1 2017

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Keywords

  • Biomaterials
  • Cell therapy
  • Drug delivery
  • Gene therapy
  • Protein engineering
  • Structural proteins

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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