Prospects for gene-based immunopharmacology in salivary glands

Seiichi Yamano, Bruce J. Baum

Research output: Contribution to journalArticle

Abstract

The clinical potential of gene transfer is increasing. One likely major application of this emerging biotechnology will be for gene therapeutics, the use of a gene as a drug. Salivary glands provide an unusual but increasingly valuable target site for gene transfer. Studies in animal salivary glands from several laboratories, including our own, have provided proof of this concept. In this review, we provide a background and perspective on possible strategies for gene-based immunopharmacology in salivary glands. We use as a target disease model the autoimmune exocrinopathy Sjogren's syndrome.

Original languageEnglish (US)
Pages (from-to)281-286
Number of pages6
JournalJapanese Journal of Pharmacology
Volume82
Issue number4
DOIs
StatePublished - 2000

Fingerprint

Salivary Glands
Genes
Sjogren's Syndrome
Therapeutic Uses
Biotechnology
Autoimmune Diseases
Pharmaceutical Preparations

Keywords

  • Adeno-associated virus
  • Autoimmune disease
  • Cytokine
  • Gene therapeutics
  • Salivary gland

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Prospects for gene-based immunopharmacology in salivary glands. / Yamano, Seiichi; Baum, Bruce J.

In: Japanese Journal of Pharmacology, Vol. 82, No. 4, 2000, p. 281-286.

Research output: Contribution to journalArticle

@article{ebb6ca0f95d64ce38e0c96bbaf217145,
title = "Prospects for gene-based immunopharmacology in salivary glands",
abstract = "The clinical potential of gene transfer is increasing. One likely major application of this emerging biotechnology will be for gene therapeutics, the use of a gene as a drug. Salivary glands provide an unusual but increasingly valuable target site for gene transfer. Studies in animal salivary glands from several laboratories, including our own, have provided proof of this concept. In this review, we provide a background and perspective on possible strategies for gene-based immunopharmacology in salivary glands. We use as a target disease model the autoimmune exocrinopathy Sjogren's syndrome.",
keywords = "Adeno-associated virus, Autoimmune disease, Cytokine, Gene therapeutics, Salivary gland",
author = "Seiichi Yamano and Baum, {Bruce J.}",
year = "2000",
doi = "10.1254/jjp.82.281",
language = "English (US)",
volume = "82",
pages = "281--286",
journal = "Japanese Journal of Pharmacology",
issn = "0021-5198",
publisher = "Japanese Pharmacological Society",
number = "4",

}

TY - JOUR

T1 - Prospects for gene-based immunopharmacology in salivary glands

AU - Yamano, Seiichi

AU - Baum, Bruce J.

PY - 2000

Y1 - 2000

N2 - The clinical potential of gene transfer is increasing. One likely major application of this emerging biotechnology will be for gene therapeutics, the use of a gene as a drug. Salivary glands provide an unusual but increasingly valuable target site for gene transfer. Studies in animal salivary glands from several laboratories, including our own, have provided proof of this concept. In this review, we provide a background and perspective on possible strategies for gene-based immunopharmacology in salivary glands. We use as a target disease model the autoimmune exocrinopathy Sjogren's syndrome.

AB - The clinical potential of gene transfer is increasing. One likely major application of this emerging biotechnology will be for gene therapeutics, the use of a gene as a drug. Salivary glands provide an unusual but increasingly valuable target site for gene transfer. Studies in animal salivary glands from several laboratories, including our own, have provided proof of this concept. In this review, we provide a background and perspective on possible strategies for gene-based immunopharmacology in salivary glands. We use as a target disease model the autoimmune exocrinopathy Sjogren's syndrome.

KW - Adeno-associated virus

KW - Autoimmune disease

KW - Cytokine

KW - Gene therapeutics

KW - Salivary gland

UR - http://www.scopus.com/inward/record.url?scp=0034063733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034063733&partnerID=8YFLogxK

U2 - 10.1254/jjp.82.281

DO - 10.1254/jjp.82.281

M3 - Article

VL - 82

SP - 281

EP - 286

JO - Japanese Journal of Pharmacology

JF - Japanese Journal of Pharmacology

SN - 0021-5198

IS - 4

ER -