Prokaryotic Systems Biology

Thadeous Kacmarczyk, Peter Waltman, Richard Bonneau

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter will briefly review the most common technologies employed in prokaryotic systems biology projects. When possible, we will highlight the relevance to prokaryotic biology and the role prokaryotic systems might have had in the inception of the technology overall.We will then walk the reader through four functional genomics projects. Although this review cannot cover all details of the full, field-wide, efforts directed at even a single organism, we do think it is instructive to attempt to outline the efforts directed to each of these systems. We wish to highlight the biological insights gleaned from these studies and demonstrate that these studies illustrate a very productive interface between systems biology, computational biology and more traditional (small numbers of genes) molecular biology that is already in operation in the studies we review.

Original languageEnglish (US)
Title of host publicationPlant Systems Biology
PublisherBlackwell Publishing Ltd
Pages67-136
Number of pages70
Volume35
ISBN (Electronic)9781444312249
ISBN (Print)9781405162838
DOIs
StatePublished - Aug 18 2009

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Keywords

  • Bacillus subtilis
  • Caulobacter crescentus
  • Escherichia coli
  • Halobacterium NRC-1
  • Halobacterium salinarum
  • Microarray
  • Network inference
  • Proteomics
  • Systems biology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Kacmarczyk, T., Waltman, P., & Bonneau, R. (2009). Prokaryotic Systems Biology. In Plant Systems Biology (Vol. 35, pp. 67-136). Blackwell Publishing Ltd. https://doi.org/10.1002/9781444312249.ch3