Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system

Filipe Pinto-Teixeira, Nikolaos Konstantinides, Claude Desplan

Research output: Contribution to journalReview article

Abstract

Nervous system development is a process that integrates cell proliferation, differentiation, and programmed cell death (PCD). PCD is an evolutionary conserved mechanism and a fundamental developmental process by which the final cell number in a nervous system is established. In vertebrates and invertebrates, PCD can be determined intrinsically by cell lineage and age, as well as extrinsically by nutritional, metabolic, and hormonal states. Drosophila has been an instrumental model for understanding how this mechanism is regulated. We review the role of PCD in Drosophila central nervous system development from neural progenitors to neurons, its molecular mechanism and function, how it is regulated and implemented, and how it ultimately shapes the fly central nervous system from the embryo to the adult. Finally, we discuss ideas that emerged while integrating this information.

Original languageEnglish (US)
Pages (from-to)2435-2453
Number of pages19
JournalFEBS Letters
DOIs
StatePublished - Aug 1 2016

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Neurology
Cell death
Drosophila
Cell Death
Central Nervous System
Nervous System
Cell proliferation
Cell Lineage
Invertebrates
Diptera
Neurons
Vertebrates
Cell Differentiation
Embryonic Structures
Cell Count
Cell Proliferation

Keywords

  • apoptosis
  • Drosophila
  • neurodevelopment

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Medicine(all)
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system. / Pinto-Teixeira, Filipe; Konstantinides, Nikolaos; Desplan, Claude.

In: FEBS Letters, 01.08.2016, p. 2435-2453.

Research output: Contribution to journalReview article

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