Programmable bio-nano-chip system: An ultra-flexible platform for bioscience and clinical measurements

G. W. Simmons, M. P. McRae, B. Shadfan, J. Wong, N. Christodoulides, P. W.M.V. Ruijven, J. P. Hayes, R. Mehalso, J. T. McDevitt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The manuscript provides a brief introduction to new programmable medical microdevice technology developed through a public-private partnership between Rice University, a startup venture called SensoDx and a manufacturing relationship with MiniFAB. Outputs of this fruitful collaboration are customizable single-use disposable cartridges that can be manufactured in high volumes and outperform all previous prototypes in terms of analytical performance, ease of use, reproducibility and cost. These labcard devices include high surface area nano-structured biomarker capture ensembles that are indexed matched to real-world biological specimens enabling high performance signaling, on-card sample volume selection, a standard process to digitize biological signatures, on-chip fluid storage in blisters and self-contained waste. These injection molded disposables with glucometer-like sampling interface are now being tested and validated in the context of major clinical trials that target significant diseases including cardiac heart disease, ovarian cancer, and prostate cancer. Initial clinical data from these 3 programmable bio-nano-chip systems are described.

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages2059-2063
Number of pages5
ISBN (Electronic)9780979806476
StatePublished - Jan 1 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

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Keywords

  • Cartridges
  • Diagnostics
  • Lab-on-a-chip
  • Microfluidics
  • Programmable bio-nano-chips

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Simmons, G. W., McRae, M. P., Shadfan, B., Wong, J., Christodoulides, N., Ruijven, P. W. M. V., Hayes, J. P., Mehalso, R., & McDevitt, J. T. (2014). Programmable bio-nano-chip system: An ultra-flexible platform for bioscience and clinical measurements. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 2059-2063). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.