Programing the formation of DNA and PNA quadruplexes by π-π-stacking interactions

Sourav Saha, Jianfeng Cai, Daniel Eiler, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

Guanine (G) rich G4T4G4 DNA and homologous PNA strands tend to form antiparallel dimeric quadruplexes. In contrast, the same DNA strands carrying planar aromatic 5′-residues preferentially form parallel DNA quadruplex. Conformation and composition of the DNA quadruplexes can be programed by π-π-stacking interaction exerted by the 5′-residues.

Original languageEnglish (US)
Pages (from-to)1685-1687
Number of pages3
JournalChemical Communications
Volume46
Issue number10
DOIs
StatePublished - 2010

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DNA
Guanine
Conformations
Chemical analysis

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Programing the formation of DNA and PNA quadruplexes by π-π-stacking interactions. / Saha, Sourav; Cai, Jianfeng; Eiler, Daniel; Hamilton, Andrew.

In: Chemical Communications, Vol. 46, No. 10, 2010, p. 1685-1687.

Research output: Contribution to journalArticle

Saha, Sourav ; Cai, Jianfeng ; Eiler, Daniel ; Hamilton, Andrew. / Programing the formation of DNA and PNA quadruplexes by π-π-stacking interactions. In: Chemical Communications. 2010 ; Vol. 46, No. 10. pp. 1685-1687.
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