Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Jason R. Porter, Mark R. Helmers, Ping Wang, Jennifer L. Furman, Stephen T. Joy, Paramjit S. Arora, Indraneel Ghosh

Research output: Contribution to journalArticle

Abstract

We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

Original languageEnglish (US)
Pages (from-to)8020-8022
Number of pages3
JournalChemical Communications
Volume46
Issue number42
DOIs
StatePublished - Nov 14 2010

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2'. Together they form a unique fingerprint.

  • Cite this