Production of NSAID pharmaceutical molecular liquids via RESS processing

Sudhir Kumar Sharma, Abiy D. Woldetsadik, Mazin Magzoub, Ramesh Jagannathan

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We report the production of pharmaceutical molecular clusters of most commonly implemented and prominent drug molecules such as ibuprofen and naproxen, via Rapid Expansion of Supercritical Solution (RESS) processing under mild conditions. These drug molecular clusters were first trapped in "dry ice" and subsequently solubilized in DI water under ambient conditions. These solutions are found to be stable over a period of several weeks. Drop casting and ambient drying of these solutions on a silicon substrate resulted in stable, viscous liquid films. Optical and electron microscopy showed typical liquid like behavior of these drop casted films. In-vitro cell viability studies, clearly demonstrated that the water-solubilized ibuprofen and naproxen exhibit similar cytotoxicity to the as received, raw drug powders thus retaining their original potency.

    Original languageEnglish (US)
    Title of host publicationBiotech, Biomaterials and Biomedical - TechConnect Briefs 2016
    PublisherTechConnect
    Pages93-96
    Number of pages4
    Volume3
    ISBN (Electronic)9780997511727
    StatePublished - Jan 1 2016
    Event10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference - Washington, United States
    Duration: May 22 2016May 25 2016

    Other

    Other10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference
    CountryUnited States
    CityWashington
    Period5/22/165/25/16

    Fingerprint

    Non-Steroidal Anti-Inflammatory Agents
    Drug products
    Naproxen
    Ibuprofen
    Liquid films
    Liquids
    Cytotoxicity
    Processing
    Pharmaceutical Preparations
    Electron microscopy
    Optical microscopy
    Ice
    Water
    Drying
    Casting
    Dry Ice
    Cells
    Powders
    Silicon
    Molecules

    Keywords

    • Drug nanoparticles
    • Ibuprofen
    • Micronization
    • RESS
    • Supercritical fluids

    ASJC Scopus subject areas

    • Fluid Flow and Transfer Processes
    • Biotechnology
    • Surfaces, Coatings and Films
    • Fuel Technology

    Cite this

    Sharma, S. K., Woldetsadik, A. D., Magzoub, M., & Jagannathan, R. (2016). Production of NSAID pharmaceutical molecular liquids via RESS processing. In Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016 (Vol. 3, pp. 93-96). TechConnect.

    Production of NSAID pharmaceutical molecular liquids via RESS processing. / Sharma, Sudhir Kumar; Woldetsadik, Abiy D.; Magzoub, Mazin; Jagannathan, Ramesh.

    Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016. Vol. 3 TechConnect, 2016. p. 93-96.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Sharma, SK, Woldetsadik, AD, Magzoub, M & Jagannathan, R 2016, Production of NSAID pharmaceutical molecular liquids via RESS processing. in Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016. vol. 3, TechConnect, pp. 93-96, 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference, Washington, United States, 5/22/16.
    Sharma SK, Woldetsadik AD, Magzoub M, Jagannathan R. Production of NSAID pharmaceutical molecular liquids via RESS processing. In Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016. Vol. 3. TechConnect. 2016. p. 93-96
    Sharma, Sudhir Kumar ; Woldetsadik, Abiy D. ; Magzoub, Mazin ; Jagannathan, Ramesh. / Production of NSAID pharmaceutical molecular liquids via RESS processing. Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016. Vol. 3 TechConnect, 2016. pp. 93-96
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