Production of NSAID pharmaceutical molecular liquids via RESS processing

Sudhir Kumar Sharma, Abiy D. Woldetsadik, Mazin Magzoub, Ramesh Jagannathan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report the production of pharmaceutical molecular clusters of most commonly implemented and prominent drug molecules such as ibuprofen and naproxen, via Rapid Expansion of Supercritical Solution (RESS) processing under mild conditions. These drug molecular clusters were first trapped in "dry ice" and subsequently solubilized in DI water under ambient conditions. These solutions are found to be stable over a period of several weeks. Drop casting and ambient drying of these solutions on a silicon substrate resulted in stable, viscous liquid films. Optical and electron microscopy showed typical liquid like behavior of these drop casted films. In-vitro cell viability studies, clearly demonstrated that the water-solubilized ibuprofen and naproxen exhibit similar cytotoxicity to the as received, raw drug powders thus retaining their original potency.

Original languageEnglish (US)
Title of host publicationBiotech, Biomaterials and Biomedical - TechConnect Briefs 2016
EditorsMatthew Laudon, Fiona Case, Fiona Case, Bart Romanowicz, Bart Romanowicz
PublisherTechConnect
Pages93-96
Number of pages4
ISBN (Electronic)9780997511727
StatePublished - Jan 1 2016
Event10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference - Washington, United States
Duration: May 22 2016May 25 2016

Publication series

NameAdvanced Materials - TechConnect Briefs 2016
Volume3

Other

Other10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference
CountryUnited States
CityWashington
Period5/22/165/25/16

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Keywords

  • Drug nanoparticles
  • Ibuprofen
  • Micronization
  • RESS
  • Supercritical fluids

ASJC Scopus subject areas

  • Fluid Flow and Transfer Processes
  • Biotechnology
  • Surfaces, Coatings and Films
  • Fuel Technology

Cite this

Sharma, S. K., Woldetsadik, A. D., Magzoub, M., & Jagannathan, R. (2016). Production of NSAID pharmaceutical molecular liquids via RESS processing. In M. Laudon, F. Case, F. Case, B. Romanowicz, & B. Romanowicz (Eds.), Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016 (pp. 93-96). (Advanced Materials - TechConnect Briefs 2016; Vol. 3). TechConnect.