Primer preactivation of peptidoglycan polymerases

Tsung Shing Andrew Wang, Tania Lupoli, Yuto Sumida, Hirokazu Tsukamoto, Yihui Wu, Yuriy Rebets, Daniel E. Kahne, Suzanne Walker

Research output: Contribution to journalArticle

Abstract

Peptidoglycan glycosyltransferases are highly conserved bacterial enzymes that catalyze glycan strand polymerization to build the cell wall. Because the cell wall is essential for bacterial cell survival, these glycosyltransferases are potential antibiotic targets, but a detailed understanding of their mechanisms is lacking. Here we show that a synthetic peptidoglycan fragment that mimics the elongating polymer chain activates peptidoglycan glycosyltransferases by bypassing the rate-limiting initiation step.

Original languageEnglish (US)
Pages (from-to)8528-8530
Number of pages3
JournalJournal of the American Chemical Society
Volume133
Issue number22
DOIs
StatePublished - Jun 8 2011

Fingerprint

Peptidoglycan Glycosyltransferase
Peptidoglycan
Cell Wall
Cells
Glycosyltransferases
Polymerization
Polysaccharides
Cell Survival
Polymers
Antibiotics
Anti-Bacterial Agents
Enzymes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Wang, T. S. A., Lupoli, T., Sumida, Y., Tsukamoto, H., Wu, Y., Rebets, Y., ... Walker, S. (2011). Primer preactivation of peptidoglycan polymerases. Journal of the American Chemical Society, 133(22), 8528-8530. https://doi.org/10.1021/ja2028712

Primer preactivation of peptidoglycan polymerases. / Wang, Tsung Shing Andrew; Lupoli, Tania; Sumida, Yuto; Tsukamoto, Hirokazu; Wu, Yihui; Rebets, Yuriy; Kahne, Daniel E.; Walker, Suzanne.

In: Journal of the American Chemical Society, Vol. 133, No. 22, 08.06.2011, p. 8528-8530.

Research output: Contribution to journalArticle

Wang, TSA, Lupoli, T, Sumida, Y, Tsukamoto, H, Wu, Y, Rebets, Y, Kahne, DE & Walker, S 2011, 'Primer preactivation of peptidoglycan polymerases', Journal of the American Chemical Society, vol. 133, no. 22, pp. 8528-8530. https://doi.org/10.1021/ja2028712
Wang TSA, Lupoli T, Sumida Y, Tsukamoto H, Wu Y, Rebets Y et al. Primer preactivation of peptidoglycan polymerases. Journal of the American Chemical Society. 2011 Jun 8;133(22):8528-8530. https://doi.org/10.1021/ja2028712
Wang, Tsung Shing Andrew ; Lupoli, Tania ; Sumida, Yuto ; Tsukamoto, Hirokazu ; Wu, Yihui ; Rebets, Yuriy ; Kahne, Daniel E. ; Walker, Suzanne. / Primer preactivation of peptidoglycan polymerases. In: Journal of the American Chemical Society. 2011 ; Vol. 133, No. 22. pp. 8528-8530.
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