Primate translational vestibuloocular reflexes. III. Effects of bilateral labyrinthine electrical stimulation

Dora E. Angelaki, M. Quinn McHenry, J. David Dickman, Adrian A. Perachio

Research output: Contribution to journalArticle

Abstract

The effects of functional, reversible ablation and potential recruitment of the most irregular otolith afferents on the dynamics and sensitivity of the translational vestibuloocular reflexes (trVORs) were investigated in rhesus monkeys trained to fixate near and far targets. Translational motion stimuli consisted of either steady-state lateral and fore-aft sinusoidal oscillations or short-lasting transient lateral head displacements. Short- duration (usually <2 s) anodal (inhibitory) and cathodal (excitatory) currents (50-100 μA) were delivered bilaterally during motion. In the presence of anodal labyrinthine stimulation, trVOR sensitivity and its dependence on viewing distance were significantly decreased. In addition, anodal currents significantly increased phase lags. During transient motion, anodal stimulation resulted in significantly lower initial eye acceleration and more sluggish responses. Cathodal currents tended to have opposite effects. The main characteristics of these results were simulated by a simple model where both regularly and irregularly discharging afferents contribute to the trVORs. Anodal labyrinthine currents also were found to decrease eye velocity during long-duration, constant velocity rotations, although results were generally more variable compared with those during translational motion.

Original languageEnglish (US)
Pages (from-to)1662-1676
Number of pages15
JournalJournal of neurophysiology
Volume83
Issue number3
StatePublished - Mar 30 2000

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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