Primary auditory cortex regulates threat memory specificity

Mattis B. Wigestrand, Hillary C. Schiff, Marianne Fyhn, Joseph Ledoux, Robert M. Sears

Research output: Contribution to journalArticle

Abstract

Distinguishing threatening from nonthreatening stimuli is essential for survival and stimulus generalization is a hallmark of anxiety disorders. While auditory threat learning produces long-lasting plasticity in primary auditory cortex (Au1), it is not clear whether such Au1 plasticity regulates memory specificity or generalization. We used muscimol infusions in rats to show that discriminatory threat learning requires Au1 activity specifically during memory acquisition and retrieval, but not during consolidation. Memory specificity was similarly disrupted by infusion of PKMz inhibitor peptide (ZIP) during memory storage. Our findings show that Au1 is required at critical memory phases and suggest that Au1 plasticity enables stimulus discrimination.

Original languageEnglish (US)
Pages (from-to)55-58
Number of pages4
JournalLearning and Memory
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Auditory Cortex
Stimulus Generalization
Learning
Muscimol
Anxiety Disorders

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Wigestrand, M. B., Schiff, H. C., Fyhn, M., Ledoux, J., & Sears, R. M. (2017). Primary auditory cortex regulates threat memory specificity. Learning and Memory, 24(1), 55-58. https://doi.org/10.1101/lm.044362.116

Primary auditory cortex regulates threat memory specificity. / Wigestrand, Mattis B.; Schiff, Hillary C.; Fyhn, Marianne; Ledoux, Joseph; Sears, Robert M.

In: Learning and Memory, Vol. 24, No. 1, 01.01.2017, p. 55-58.

Research output: Contribution to journalArticle

Wigestrand, MB, Schiff, HC, Fyhn, M, Ledoux, J & Sears, RM 2017, 'Primary auditory cortex regulates threat memory specificity', Learning and Memory, vol. 24, no. 1, pp. 55-58. https://doi.org/10.1101/lm.044362.116
Wigestrand, Mattis B. ; Schiff, Hillary C. ; Fyhn, Marianne ; Ledoux, Joseph ; Sears, Robert M. / Primary auditory cortex regulates threat memory specificity. In: Learning and Memory. 2017 ; Vol. 24, No. 1. pp. 55-58.
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