Prevention of ECS-induced amnesia by reestablishing continuity with the training situation

Efrain Azmitia, Bruce S. McEwen, David Quartermain

Research output: Contribution to journalArticle

Abstract

Retrograde amnesia for a passive avoidance task was produced in rats by electroconvulsive shock (ECS). However, if rats were left to recover for 15 min in the training apparatus after receiving a foot shock-ECS combination, they showed no sign of amnesia at testing 24-hr later. ECS alone without training had no effect on the step-out latencies. Amnesia did occur when the place of training was different from the place of recovery. The results suggest that a core memory survives ECS treatment and that this surviving trace is retrievable at the retest trial if continuity with the preceding experimental events is established upon recovery from the black-out produced by ECS.

Original languageEnglish (US)
Pages (from-to)853-855
Number of pages3
JournalPhysiology and Behavior
Volume8
Issue number5
DOIs
StatePublished - 1972

Fingerprint

Electroshock
Amnesia
Retrograde Amnesia
Foot
Shock

Keywords

  • ECS
  • Passive avoidance
  • Retrograde amnesia

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Prevention of ECS-induced amnesia by reestablishing continuity with the training situation. / Azmitia, Efrain; McEwen, Bruce S.; Quartermain, David.

In: Physiology and Behavior, Vol. 8, No. 5, 1972, p. 853-855.

Research output: Contribution to journalArticle

Azmitia, Efrain ; McEwen, Bruce S. ; Quartermain, David. / Prevention of ECS-induced amnesia by reestablishing continuity with the training situation. In: Physiology and Behavior. 1972 ; Vol. 8, No. 5. pp. 853-855.
@article{e48d5a162e054696bd9c48734584ffc3,
title = "Prevention of ECS-induced amnesia by reestablishing continuity with the training situation",
abstract = "Retrograde amnesia for a passive avoidance task was produced in rats by electroconvulsive shock (ECS). However, if rats were left to recover for 15 min in the training apparatus after receiving a foot shock-ECS combination, they showed no sign of amnesia at testing 24-hr later. ECS alone without training had no effect on the step-out latencies. Amnesia did occur when the place of training was different from the place of recovery. The results suggest that a core memory survives ECS treatment and that this surviving trace is retrievable at the retest trial if continuity with the preceding experimental events is established upon recovery from the black-out produced by ECS.",
keywords = "ECS, Passive avoidance, Retrograde amnesia",
author = "Efrain Azmitia and McEwen, {Bruce S.} and David Quartermain",
year = "1972",
doi = "10.1016/0031-9384(72)90296-X",
language = "English (US)",
volume = "8",
pages = "853--855",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Prevention of ECS-induced amnesia by reestablishing continuity with the training situation

AU - Azmitia, Efrain

AU - McEwen, Bruce S.

AU - Quartermain, David

PY - 1972

Y1 - 1972

N2 - Retrograde amnesia for a passive avoidance task was produced in rats by electroconvulsive shock (ECS). However, if rats were left to recover for 15 min in the training apparatus after receiving a foot shock-ECS combination, they showed no sign of amnesia at testing 24-hr later. ECS alone without training had no effect on the step-out latencies. Amnesia did occur when the place of training was different from the place of recovery. The results suggest that a core memory survives ECS treatment and that this surviving trace is retrievable at the retest trial if continuity with the preceding experimental events is established upon recovery from the black-out produced by ECS.

AB - Retrograde amnesia for a passive avoidance task was produced in rats by electroconvulsive shock (ECS). However, if rats were left to recover for 15 min in the training apparatus after receiving a foot shock-ECS combination, they showed no sign of amnesia at testing 24-hr later. ECS alone without training had no effect on the step-out latencies. Amnesia did occur when the place of training was different from the place of recovery. The results suggest that a core memory survives ECS treatment and that this surviving trace is retrievable at the retest trial if continuity with the preceding experimental events is established upon recovery from the black-out produced by ECS.

KW - ECS

KW - Passive avoidance

KW - Retrograde amnesia

UR - http://www.scopus.com/inward/record.url?scp=0015341023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015341023&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(72)90296-X

DO - 10.1016/0031-9384(72)90296-X

M3 - Article

C2 - 5065275

AN - SCOPUS:0015341023

VL - 8

SP - 853

EP - 855

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 5

ER -